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Article: Cetylpyridinium Chloride Mouth Rinses Alleviate Experimental Gingivitis by Inhibiting Dental Plaque Maturation

TitleCetylpyridinium Chloride Mouth Rinses Alleviate Experimental Gingivitis by Inhibiting Dental Plaque Maturation
Authors
KeywordsCetylpyridinium chloride
oral microbiota
oral rinse
Issue Date2016
Citation
International Journal of Oral Science, 2016, v. 8, n. 3, p. 182-190 How to Cite?
AbstractOral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double-blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis-enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.
Persistent Identifierhttp://hdl.handle.net/10722/311415
ISSN
2023 Impact Factor: 10.8
2023 SCImago Journal Rankings: 2.596
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTeng, Fei-
dc.contributor.authorHe, Tao-
dc.contributor.authorHuang, Shi-
dc.contributor.authorBo, Cun Pei-
dc.contributor.authorLi, Zhen-
dc.contributor.authorChang, Jin Lan-
dc.contributor.authorLiu, Ji Quan-
dc.contributor.authorCharbonneau, Duane-
dc.contributor.authorXu, Jian-
dc.contributor.authorLi, Rui-
dc.contributor.authorLing, Jun Qi-
dc.date.accessioned2022-03-22T11:53:53Z-
dc.date.available2022-03-22T11:53:53Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Oral Science, 2016, v. 8, n. 3, p. 182-190-
dc.identifier.issn1674-2818-
dc.identifier.urihttp://hdl.handle.net/10722/311415-
dc.description.abstractOral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double-blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis-enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Oral Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCetylpyridinium chloride-
dc.subjectoral microbiota-
dc.subjectoral rinse-
dc.titleCetylpyridinium Chloride Mouth Rinses Alleviate Experimental Gingivitis by Inhibiting Dental Plaque Maturation-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/ijos.2016.18-
dc.identifier.pmid27680288-
dc.identifier.pmcidPMC5113089-
dc.identifier.scopuseid_2-s2.0-84989328288-
dc.identifier.volume8-
dc.identifier.issue3-
dc.identifier.spage182-
dc.identifier.epage190-
dc.identifier.eissn2049-3169-
dc.identifier.isiWOS:000385468800007-

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