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Article: Prospective clinical trial on the learning curve of high-intensity-focused ultrasound for the treatment of breast fibroadenoma

TitleProspective clinical trial on the learning curve of high-intensity-focused ultrasound for the treatment of breast fibroadenoma
Authors
KeywordsFibroadenoma
High-intensity-focused ultrasound
Learning curve
Issue Date2022
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00595/index.htm
Citation
Surgery Today, 2022, v. 52 n. 7, p. 1048-1053 How to Cite?
AbstractIntroduction: High-intensity-focused ultrasound (HIFU) is a safe and feasible treatment option for breast fibroadenoma. However, its learning curve has not been described in the medical literature. Methods: All patients with biopsy-proven fibroadenoma considered indicated for HIFU were screened for eligibility for HIFU treatment. A total of 60 patients were recruited according to the pre-defined sample size calculation. Results: Sixty consecutive patients were divided into three cohorts in chronological order. The mean tumor volume shrinkage rates in cohorts 1, 2, and 3 at 6 months post-HIFU ablation were 38%, 34%, and 59%, respectively. Significant tumor shrinkage was observed from case 41 onward (p < 0.0001). Similarly, the mean tumor volume shrinkage rates in cohorts 1, 2, and 3 at 12 months post-HIFU ablation were 45%, 51%, and 71%, respectively. Significant tumor shrinkage was observed from case 41 onwards (p < 0.0473). The mean procedure time for the first 20 patients was 48.5 (range 45-75) minutes, while that in the second 20 patients was 39.7 (range 20-60) minutes, and that in the last 20 patients was 28.9 (range 15-45) minutes. The treatment time was significantly shorter from case 41 onwards (p = 0.0481). Conclusion: Treatment outcomes and treatment time improved significantly after performing approximately 40 HIFU procedures.
Persistent Identifierhttp://hdl.handle.net/10722/310602
ISSN
2023 Impact Factor: 1.7
2023 SCImago Journal Rankings: 0.719
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCo, THM-
dc.contributor.authorChen, THC-
dc.contributor.authorLee, C-
dc.contributor.authorYu, S-
dc.contributor.authorKwong, A-
dc.date.accessioned2022-02-07T07:59:07Z-
dc.date.available2022-02-07T07:59:07Z-
dc.date.issued2022-
dc.identifier.citationSurgery Today, 2022, v. 52 n. 7, p. 1048-1053-
dc.identifier.issn0941-1291-
dc.identifier.urihttp://hdl.handle.net/10722/310602-
dc.description.abstractIntroduction: High-intensity-focused ultrasound (HIFU) is a safe and feasible treatment option for breast fibroadenoma. However, its learning curve has not been described in the medical literature. Methods: All patients with biopsy-proven fibroadenoma considered indicated for HIFU were screened for eligibility for HIFU treatment. A total of 60 patients were recruited according to the pre-defined sample size calculation. Results: Sixty consecutive patients were divided into three cohorts in chronological order. The mean tumor volume shrinkage rates in cohorts 1, 2, and 3 at 6 months post-HIFU ablation were 38%, 34%, and 59%, respectively. Significant tumor shrinkage was observed from case 41 onward (p < 0.0001). Similarly, the mean tumor volume shrinkage rates in cohorts 1, 2, and 3 at 12 months post-HIFU ablation were 45%, 51%, and 71%, respectively. Significant tumor shrinkage was observed from case 41 onwards (p < 0.0473). The mean procedure time for the first 20 patients was 48.5 (range 45-75) minutes, while that in the second 20 patients was 39.7 (range 20-60) minutes, and that in the last 20 patients was 28.9 (range 15-45) minutes. The treatment time was significantly shorter from case 41 onwards (p = 0.0481). Conclusion: Treatment outcomes and treatment time improved significantly after performing approximately 40 HIFU procedures.-
dc.languageeng-
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00595/index.htm-
dc.relation.ispartofSurgery Today-
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/[insert DOI]-
dc.subjectFibroadenoma-
dc.subjectHigh-intensity-focused ultrasound-
dc.subjectLearning curve-
dc.titleProspective clinical trial on the learning curve of high-intensity-focused ultrasound for the treatment of breast fibroadenoma-
dc.typeArticle-
dc.identifier.emailCo, THM: mcth@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityCo, THM=rp02101-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00595-021-02421-3-
dc.identifier.pmid35000002-
dc.identifier.scopuseid_2-s2.0-85122648255-
dc.identifier.hkuros331661-
dc.identifier.volume52-
dc.identifier.issue7-
dc.identifier.spage1048-
dc.identifier.epage1053-
dc.identifier.isiWOS:000740425200001-
dc.publisher.placeJapan-

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