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Article: Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis

TitleAltered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
Authors
Keywordsrisk taking
risky decision-making
bipolar disorder
psychosis
BART 2
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry
Citation
Frontiers in Psychiatry, 2021, v. 12, p. article no. 763545 How to Cite?
AbstractAltered risk-taking propensity is an important determinant of functional impairment in bipolar disorder. However, prior studies primarily assessed patients with chronic illness, and risk-taking has not been evaluated in the early illness course. This study investigated risk-taking behavior in 39 euthymic early-stage bipolar disorder patients aged 16–40 years who were treated within 3 years from their first-episode mania with psychotic features and 36 demographically-matched healthy controls using the Balloon Analog Risk Task (BART), a well-validated risk-taking performance-based paradigm requiring participants to make responses for cumulative gain at increasing risk of loss. Relationships of risk-taking indices with symptoms, self-reported impulsivity, cognitive functions, and treatment characteristics were also assessed. Our results showed that patients exhibited significantly lower adjusted scores (i.e., average balloon pumps in unexploded trials) (p = 0.001), lower explosion rate (p = 0.007) and lower cumulative scores (p = 0.003) than controls on BART, indicating their suboptimal risk-taking performance with increased propensity for risk aversion. Risk-taking indices were not correlated with any symptom dimensions, self-reported impulsivity, cognitive functions or antipsychotic dose. No significant difference was observed between patients with and without antipsychotic medications on self-reported impulsivity or any of the BART performance indices. This is the first study to examine risk-taking behavior in early-stage bipolar disorder with history of psychosis and indicates that patients displayed altered risk-taking with increased risk aversion compared with controls. Further research is needed to clarify longitudinal trajectory of risk-taking propensity and its relationships with psychosis and functional outcome in the early stage of bipolar disorder.
Persistent Identifierhttp://hdl.handle.net/10722/310596
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.155
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, SCY-
dc.contributor.authorNg, MMC-
dc.contributor.authorCHAN, JKN-
dc.contributor.authorLuk, MSK-
dc.contributor.authorLui, SSY-
dc.contributor.authorChen, EYH-
dc.contributor.authorChang, WC-
dc.date.accessioned2022-02-07T07:59:01Z-
dc.date.available2022-02-07T07:59:01Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Psychiatry, 2021, v. 12, p. article no. 763545-
dc.identifier.issn1664-0640-
dc.identifier.urihttp://hdl.handle.net/10722/310596-
dc.description.abstractAltered risk-taking propensity is an important determinant of functional impairment in bipolar disorder. However, prior studies primarily assessed patients with chronic illness, and risk-taking has not been evaluated in the early illness course. This study investigated risk-taking behavior in 39 euthymic early-stage bipolar disorder patients aged 16–40 years who were treated within 3 years from their first-episode mania with psychotic features and 36 demographically-matched healthy controls using the Balloon Analog Risk Task (BART), a well-validated risk-taking performance-based paradigm requiring participants to make responses for cumulative gain at increasing risk of loss. Relationships of risk-taking indices with symptoms, self-reported impulsivity, cognitive functions, and treatment characteristics were also assessed. Our results showed that patients exhibited significantly lower adjusted scores (i.e., average balloon pumps in unexploded trials) (p = 0.001), lower explosion rate (p = 0.007) and lower cumulative scores (p = 0.003) than controls on BART, indicating their suboptimal risk-taking performance with increased propensity for risk aversion. Risk-taking indices were not correlated with any symptom dimensions, self-reported impulsivity, cognitive functions or antipsychotic dose. No significant difference was observed between patients with and without antipsychotic medications on self-reported impulsivity or any of the BART performance indices. This is the first study to examine risk-taking behavior in early-stage bipolar disorder with history of psychosis and indicates that patients displayed altered risk-taking with increased risk aversion compared with controls. Further research is needed to clarify longitudinal trajectory of risk-taking propensity and its relationships with psychosis and functional outcome in the early stage of bipolar disorder.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry-
dc.relation.ispartofFrontiers in Psychiatry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectrisk taking-
dc.subjectrisky decision-making-
dc.subjectbipolar disorder-
dc.subjectpsychosis-
dc.subjectBART 2-
dc.titleAltered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis-
dc.typeArticle-
dc.identifier.emailLui, SSY: lsy570@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.authorityLui, SSY=rp02747-
dc.identifier.authorityChen, EYH=rp00392-
dc.identifier.authorityChang, WC=rp01465-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fpsyt.2021.763545-
dc.identifier.pmid34867547-
dc.identifier.pmcidPMC8637446-
dc.identifier.scopuseid_2-s2.0-85120676574-
dc.identifier.hkuros331665-
dc.identifier.volume12-
dc.identifier.spagearticle no. 763545-
dc.identifier.epagearticle no. 763545-
dc.identifier.isiWOS:000887803200001-
dc.publisher.placeSwitzerland-

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