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Article: Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

TitleIdentification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses
Authors
Keywordsbats
coronavirus
COVID-19
evolution
phylogeny
porcine epidemic diarrhea virus
SARS-CoV-2
spike protein
swine acute diarrhea syndrome
Issue Date2021
Citation
Cell, 2021, v. 184, n. 17, p. 4380-4391.e14 How to Cite?
AbstractDespite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hotspots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV.
Persistent Identifierhttp://hdl.handle.net/10722/309565
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Hong-
dc.contributor.authorJi, Jingkai-
dc.contributor.authorChen, Xing-
dc.contributor.authorBi, Yuhai-
dc.contributor.authorLi, Juan-
dc.contributor.authorWang, Qihui-
dc.contributor.authorHu, Tao-
dc.contributor.authorSong, Hao-
dc.contributor.authorZhao, Runchu-
dc.contributor.authorChen, Yanhua-
dc.contributor.authorCui, Mingxue-
dc.contributor.authorZhang, Yanyan-
dc.contributor.authorHughes, Alice C.-
dc.contributor.authorHolmes, Edward C.-
dc.contributor.authorShi, Weifeng-
dc.date.accessioned2021-12-29T07:02:44Z-
dc.date.available2021-12-29T07:02:44Z-
dc.date.issued2021-
dc.identifier.citationCell, 2021, v. 184, n. 17, p. 4380-4391.e14-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/309565-
dc.description.abstractDespite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hotspots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV.-
dc.languageeng-
dc.relation.ispartofCell-
dc.subjectbats-
dc.subjectcoronavirus-
dc.subjectCOVID-19-
dc.subjectevolution-
dc.subjectphylogeny-
dc.subjectporcine epidemic diarrhea virus-
dc.subjectSARS-CoV-2-
dc.subjectspike protein-
dc.subjectswine acute diarrhea syndrome-
dc.titleIdentification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.cell.2021.06.008-
dc.identifier.pmid34147139-
dc.identifier.pmcidPMC8188299-
dc.identifier.scopuseid_2-s2.0-85108280237-
dc.identifier.volume184-
dc.identifier.issue17-
dc.identifier.spage4380-
dc.identifier.epage4391.e14-
dc.identifier.eissn1097-4172-
dc.identifier.isiWOS:000686554600004-

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