File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.pnpbp.2021.110456
- Scopus: eid_2-s2.0-85117719891
- PMID: 34662694
- WOS: WOS:000714736100001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio)
Title | The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio) |
---|---|
Authors | |
Keywords | Zebrafish Behavioral sensitization Morphine Drug addiction |
Issue Date | 2022 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp |
Citation | Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2022, v. 113, article no. 110456 How to Cite? |
Abstract | Background:
Accumulating evidence suggest that behavioral sensitization is involved in the process of drug addiction. Zebrafish are sensitive to a variety of addictive drugs and are thus suitable for the study of behavioral sensitization. However, in contrast to mature rodent models of behavioral sensitization, how this phenomenon manifests in aquatic organisms, especially zebrafish, is largely unknown. In this study, we developed a morphine-induced behavioral sensitization adult zebrafish model and performed a preliminary investigation of the underlying mechanisms.
Methods:
Behavioral sensitization was established in zebrafish by observing their behavior after treatment and challenge with morphine. The effect of morphine was evaluated by a behavioral locomotor test. Different doses of morphine and withdrawal times were used to evaluate the establishment of the behavioral sensitization model.
Results:
Hyperlocomotion was induced after administration of morphine in adult zebrafish. After withdrawing the drug for a period, challenge with low-dose morphine evoked behavioral sensitization in zebrafish acutely pre-treated with morphine. Low-dose morphine failed to induce behavioral sensitization in zebrafish if the withdrawal time was less than 5 days or more than 7 days. Morphine induced behavioral sensitization in zebrafish may involve dopaminergic, glutamatergic and opioid systems.
Conclusion:
A single low-dose of morphine could induce behavioral sensitization in zebrafish acutely pre-treated with morphine, and this phenomenon was highly correlated with drug dose and withdrawal time. These findings suggest that zebrafish is a suitable model for the study of behavioral sensitization. |
Persistent Identifier | http://hdl.handle.net/10722/309109 |
ISSN | 2021 Impact Factor: 5.201 2020 SCImago Journal Rankings: 1.716 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bian, Y | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Liang, JH | - |
dc.contributor.author | Li, L | - |
dc.contributor.author | Wu, X | - |
dc.contributor.author | Tang, B | - |
dc.contributor.author | Leung, GPH | - |
dc.contributor.author | Lee, SMY | - |
dc.date.accessioned | 2021-12-14T01:40:41Z | - |
dc.date.available | 2021-12-14T01:40:41Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2022, v. 113, article no. 110456 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | http://hdl.handle.net/10722/309109 | - |
dc.description.abstract | Background: Accumulating evidence suggest that behavioral sensitization is involved in the process of drug addiction. Zebrafish are sensitive to a variety of addictive drugs and are thus suitable for the study of behavioral sensitization. However, in contrast to mature rodent models of behavioral sensitization, how this phenomenon manifests in aquatic organisms, especially zebrafish, is largely unknown. In this study, we developed a morphine-induced behavioral sensitization adult zebrafish model and performed a preliminary investigation of the underlying mechanisms. Methods: Behavioral sensitization was established in zebrafish by observing their behavior after treatment and challenge with morphine. The effect of morphine was evaluated by a behavioral locomotor test. Different doses of morphine and withdrawal times were used to evaluate the establishment of the behavioral sensitization model. Results: Hyperlocomotion was induced after administration of morphine in adult zebrafish. After withdrawing the drug for a period, challenge with low-dose morphine evoked behavioral sensitization in zebrafish acutely pre-treated with morphine. Low-dose morphine failed to induce behavioral sensitization in zebrafish if the withdrawal time was less than 5 days or more than 7 days. Morphine induced behavioral sensitization in zebrafish may involve dopaminergic, glutamatergic and opioid systems. Conclusion: A single low-dose of morphine could induce behavioral sensitization in zebrafish acutely pre-treated with morphine, and this phenomenon was highly correlated with drug dose and withdrawal time. These findings suggest that zebrafish is a suitable model for the study of behavioral sensitization. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp | - |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology & Biological Psychiatry | - |
dc.subject | Zebrafish | - |
dc.subject | Behavioral sensitization | - |
dc.subject | Morphine | - |
dc.subject | Drug addiction | - |
dc.title | The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio) | - |
dc.type | Article | - |
dc.identifier.email | Leung, GPH: gphleung@hkucc.hku.hk | - |
dc.identifier.authority | Leung, GPH=rp00234 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.pnpbp.2021.110456 | - |
dc.identifier.pmid | 34662694 | - |
dc.identifier.scopus | eid_2-s2.0-85117719891 | - |
dc.identifier.hkuros | 330879 | - |
dc.identifier.volume | 113 | - |
dc.identifier.spage | article no. 110456 | - |
dc.identifier.epage | article no. 110456 | - |
dc.identifier.isi | WOS:000714736100001 | - |
dc.publisher.place | United States | - |