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- Publisher Website: 10.1038/s41598-021-97099-5
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Article: Mendelian randomization study of interleukin (IL)-1 family and lung cancer
Title | Mendelian randomization study of interleukin (IL)-1 family and lung cancer |
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Authors | |
Issue Date | 2021 |
Publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2021, v. 11, article no. 17606 How to Cite? |
Abstract | The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding. We appraised the association of IL-1 family members/receptors with lung cancer and its subtypes [lung adenocarcinoma (LUAD) and squamous cell lung cancer (LUSC)] using two-sample Mendelian randomization. This study found that no IL-1 family members/receptors were significantly associated with lung cancer and its subtypes risk after correction for multiple testing. However, suggestive total effects of increased risk were noted for genetically predicted IL-1Racp with lung cancer (P = 0.006), IL-1α with LUAD (P = 0.027), and IL-1Racp with LUSC (P = 0.008). Suggestive direct effects were also noted for IL-1β, IL-1Ra, IL-36γ with lung cancer, IL-1α/β, IL-1Ra with LUAD, and IL-1β, IL-18BP with LUSC, after adjusting for genetically predicted effects of other IL-1 family members/receptors. Taken together, our findings suggest that interventions decreasing IL-1Racp might protect against lung cancer, perhaps via IL-1α/β or IL-1Ra. |
Persistent Identifier | http://hdl.handle.net/10722/309072 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yang, Z | - |
dc.contributor.author | Schooling, CM | - |
dc.contributor.author | Kwok, MK | - |
dc.date.accessioned | 2021-12-14T01:40:12Z | - |
dc.date.available | 2021-12-14T01:40:12Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Scientific Reports, 2021, v. 11, article no. 17606 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/309072 | - |
dc.description.abstract | The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding. We appraised the association of IL-1 family members/receptors with lung cancer and its subtypes [lung adenocarcinoma (LUAD) and squamous cell lung cancer (LUSC)] using two-sample Mendelian randomization. This study found that no IL-1 family members/receptors were significantly associated with lung cancer and its subtypes risk after correction for multiple testing. However, suggestive total effects of increased risk were noted for genetically predicted IL-1Racp with lung cancer (P = 0.006), IL-1α with LUAD (P = 0.027), and IL-1Racp with LUSC (P = 0.008). Suggestive direct effects were also noted for IL-1β, IL-1Ra, IL-36γ with lung cancer, IL-1α/β, IL-1Ra with LUAD, and IL-1β, IL-18BP with LUSC, after adjusting for genetically predicted effects of other IL-1 family members/receptors. Taken together, our findings suggest that interventions decreasing IL-1Racp might protect against lung cancer, perhaps via IL-1α/β or IL-1Ra. | - |
dc.language | eng | - |
dc.publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Mendelian randomization study of interleukin (IL)-1 family and lung cancer | - |
dc.type | Article | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.email | Kwok, MK: maggiek@hku.hk | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.identifier.authority | Kwok, MK=rp02051 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-021-97099-5 | - |
dc.identifier.pmid | 34475499 | - |
dc.identifier.pmcid | PMC8413403 | - |
dc.identifier.scopus | eid_2-s2.0-85114596106 | - |
dc.identifier.hkuros | 330792 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 17606 | - |
dc.identifier.epage | article no. 17606 | - |
dc.identifier.isi | WOS:000702017500082 | - |
dc.publisher.place | United Kingdom | - |