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Article: Spray-Dried Powder Formulation of Capreomycin Designed for Inhaled Tuberculosis Therapy

TitleSpray-Dried Powder Formulation of Capreomycin Designed for Inhaled Tuberculosis Therapy
Authors
KeywordsCapreomycin
Dry powder aerosol
Inhalation
Pulmonary delivery
Spray drying
Tuberculosis
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/pharmaceuticals/
Citation
Pharmaceutics, 2021, v. 13 n. 12, article no. 2044 How to Cite?
AbstractMulti-drug-resistant tuberculosis (MDR-TB) is a huge public health problem. The treatment regimen of MDR-TB requires prolonged chemotherapy with multiple drugs including second-line anti-TB agents associated with severe adverse effects. Capreomycin, a polypeptide antibiotic, is the first choice of second-line anti-TB drugs in MDR-TB therapy. It requires repeated intramuscular or intravenous administration five times per week. Pulmonary drug delivery is non-invasive with the advantages of local targeting and reduced risk of systemic toxicity. In this study, inhaled dry powder formulation of capreomycin targeting the lung was developed using spray drying technique. Among the 16 formulations designed, the one containing 25% capreomycin (w/w) and spray-dried at an inlet temperature of 90 °C showed the best overall performance with the mass median aerodynamic diameter (MMAD) of 3.38 μm and a fine particle fraction (FPF) of around 65%. In the pharmacokinetic study in mice, drug concentration in the lungs was approximately 8-fold higher than the minimum inhibitory concentration (MIC) (1.25 to 2.5 µg/mL) for at least 24 h following intratracheal administration (20 mg/kg). Compared to intravenous injection, inhaled capreomycin showed significantly higher area under the curve, slower clearance and longer mean residence time in both the lungs and plasma.
Persistent Identifierhttp://hdl.handle.net/10722/308953
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 0.845
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShao, Z-
dc.contributor.authorTai, W-
dc.contributor.authorQiu, Y-
dc.contributor.authorMan, RCH-
dc.contributor.authorLiao, Q-
dc.contributor.authorChow, MYT-
dc.contributor.authorKwok, PCL-
dc.contributor.authorLam, JKW-
dc.date.accessioned2021-12-14T01:38:38Z-
dc.date.available2021-12-14T01:38:38Z-
dc.date.issued2021-
dc.identifier.citationPharmaceutics, 2021, v. 13 n. 12, article no. 2044-
dc.identifier.issn1424-8247-
dc.identifier.urihttp://hdl.handle.net/10722/308953-
dc.description.abstractMulti-drug-resistant tuberculosis (MDR-TB) is a huge public health problem. The treatment regimen of MDR-TB requires prolonged chemotherapy with multiple drugs including second-line anti-TB agents associated with severe adverse effects. Capreomycin, a polypeptide antibiotic, is the first choice of second-line anti-TB drugs in MDR-TB therapy. It requires repeated intramuscular or intravenous administration five times per week. Pulmonary drug delivery is non-invasive with the advantages of local targeting and reduced risk of systemic toxicity. In this study, inhaled dry powder formulation of capreomycin targeting the lung was developed using spray drying technique. Among the 16 formulations designed, the one containing 25% capreomycin (w/w) and spray-dried at an inlet temperature of 90 °C showed the best overall performance with the mass median aerodynamic diameter (MMAD) of 3.38 μm and a fine particle fraction (FPF) of around 65%. In the pharmacokinetic study in mice, drug concentration in the lungs was approximately 8-fold higher than the minimum inhibitory concentration (MIC) (1.25 to 2.5 µg/mL) for at least 24 h following intratracheal administration (20 mg/kg). Compared to intravenous injection, inhaled capreomycin showed significantly higher area under the curve, slower clearance and longer mean residence time in both the lungs and plasma.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/pharmaceuticals/-
dc.relation.ispartofPharmaceutics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCapreomycin-
dc.subjectDry powder aerosol-
dc.subjectInhalation-
dc.subjectPulmonary delivery-
dc.subjectSpray drying-
dc.subjectTuberculosis-
dc.titleSpray-Dried Powder Formulation of Capreomycin Designed for Inhaled Tuberculosis Therapy-
dc.typeArticle-
dc.identifier.emailQiu, Y: qiuysh@hku.hk-
dc.identifier.emailLam, JKW: jkwlam@hku.hk-
dc.identifier.authorityLam, JKW=rp01346-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/pharmaceutics13122044-
dc.identifier.pmid34959328-
dc.identifier.pmcidPMC8706516-
dc.identifier.scopuseid_2-s2.0-85120816334-
dc.identifier.hkuros331098-
dc.identifier.volume13-
dc.identifier.issue12-
dc.identifier.spagearticle no. 2044-
dc.identifier.epagearticle no. 2044-
dc.identifier.isiWOS:000736812700001-
dc.publisher.placeSwitzerland-

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