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Article: The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway

TitleThe Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway
Authors
Issue Date2021
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/
Citation
Oxidative Medicine and Cellular Longevity, 2021, v. 2021, p. article no. 5187569 How to Cite?
AbstractBreast cancer (BCa) is the leading cause of women’s death worldwide; among them, triple-negative breast cancer (TNBC) is one of the most troublesome subtypes with easy recurrence and great aggressive properties. Spatholobus suberectus Dunn has been used in the clinic of Chinese society for hundreds of years. Shreds of evidence showed that Spatholobus suberectus Dunn has a favorable outcome in the management of cancer. However, the anti-TNBC efficacy of Spatholobus suberectus Dunn percolation extract (SSP) and its underlying mechanisms have not been fully elucidated. Hence, the present study is aimed at evaluating the anti-TNBC potential of SSP both in vitro and in vivo, through the cell viability, morphological analysis of MDA-MB-231, LDH release assay, ROS assay, and the tests of GSH aborted pyroptotic noninflammasome signaling pathway. Survival analysis using the KM Plotter and TNM plot database exhibited the inhibition of transcription levels of caspase-4 and 9 related to low relapse-free survival in patients with BCa. Based on the findings, SSP possesses anti-TNBC efficacy that relies on ROS-induced noncanonical inflammasome pyroptosis in cancer cells. In this study, our preclinical evidence is complementary to the preceding clinic of Chinese society; studies on the active principles of SPP remain underway in our laboratory.
Persistent Identifierhttp://hdl.handle.net/10722/308541
ISSN
2020 Impact Factor: 6.543
2020 SCImago Journal Rankings: 1.494
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZHANG, F-
dc.contributor.authorLIU, Q-
dc.contributor.authorGanesan, K-
dc.contributor.authorZeng, K-
dc.contributor.authorShen, J-
dc.contributor.authorFang, G-
dc.contributor.authorLuo, X-
dc.contributor.authorChen, J-
dc.date.accessioned2021-12-01T07:54:42Z-
dc.date.available2021-12-01T07:54:42Z-
dc.date.issued2021-
dc.identifier.citationOxidative Medicine and Cellular Longevity, 2021, v. 2021, p. article no. 5187569-
dc.identifier.issn1942-0900-
dc.identifier.urihttp://hdl.handle.net/10722/308541-
dc.description.abstractBreast cancer (BCa) is the leading cause of women’s death worldwide; among them, triple-negative breast cancer (TNBC) is one of the most troublesome subtypes with easy recurrence and great aggressive properties. Spatholobus suberectus Dunn has been used in the clinic of Chinese society for hundreds of years. Shreds of evidence showed that Spatholobus suberectus Dunn has a favorable outcome in the management of cancer. However, the anti-TNBC efficacy of Spatholobus suberectus Dunn percolation extract (SSP) and its underlying mechanisms have not been fully elucidated. Hence, the present study is aimed at evaluating the anti-TNBC potential of SSP both in vitro and in vivo, through the cell viability, morphological analysis of MDA-MB-231, LDH release assay, ROS assay, and the tests of GSH aborted pyroptotic noninflammasome signaling pathway. Survival analysis using the KM Plotter and TNM plot database exhibited the inhibition of transcription levels of caspase-4 and 9 related to low relapse-free survival in patients with BCa. Based on the findings, SSP possesses anti-TNBC efficacy that relies on ROS-induced noncanonical inflammasome pyroptosis in cancer cells. In this study, our preclinical evidence is complementary to the preceding clinic of Chinese society; studies on the active principles of SPP remain underway in our laboratory.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/-
dc.relation.ispartofOxidative Medicine and Cellular Longevity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleThe Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway-
dc.typeArticle-
dc.identifier.emailGanesan, K: kumarg@hku.hk-
dc.identifier.emailShen, J: shenjg@hku.hk-
dc.identifier.emailChen, J: abchen@hkucc.hku.hk-
dc.identifier.authorityShen, J=rp00487-
dc.identifier.authorityChen, J=rp01316-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2021/5187569-
dc.identifier.pmid34659633-
dc.identifier.pmcidPMC8514942-
dc.identifier.scopuseid_2-s2.0-85117422222-
dc.identifier.hkuros330435-
dc.identifier.volume2021-
dc.identifier.spagearticle no. 5187569-
dc.identifier.epagearticle no. 5187569-
dc.identifier.isiWOS:000710717500003-
dc.publisher.placeUnited States-

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