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Article: Interspecies Jumping of Bat Coronaviruses
Title | Interspecies Jumping of Bat Coronaviruses |
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Authors | |
Keywords | Interspecies jumping Bat Coronavirus Outbreak Epidemic Pandemic SARS MERS SADS COVID-19 |
Issue Date | 2021 |
Publisher | Molecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses |
Citation | Viruses, 2021, v. 13 n. 11, article no. 2188 How to Cite? |
Abstract | In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and civets and genomic studies have confirmed bat-to-civet-to-human transmission. The MERS epidemic that emerged in 2012 had a ~35% mortality, with dromedaries as the reservoir. Although CoVs with the same genome organization (e.g., Tylonycteris BatCoV HKU4 and Pipistrellus BatCoV HKU5) were also detected in bats, there is still a phylogenetic gap between these bat CoVs and MERS-CoV. In 2016, 10 years after the discovery of Rhinolophus BatCoV HKU2 in Chinese horseshoe bats, fatal swine disease outbreaks caused by this virus were reported in southern China. In late 2019, an outbreak of pneumonia emerged in Wuhan, China, and rapidly spread globally, leading to >4,000,000 fatalities so far. Although the genome of SARS-CoV-2 is highly similar to that of SARS-CoV, patient zero and the original source of the pandemic are still unknown. To protect humans from future public health threats, measures should be taken to monitor and reduce the chance of interspecies jumping events, either occurring naturally or through recombineering experiments. |
Persistent Identifier | http://hdl.handle.net/10722/308388 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.140 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, ACP | - |
dc.contributor.author | Lau, SKP | - |
dc.contributor.author | Woo, PCY | - |
dc.date.accessioned | 2021-12-01T07:52:40Z | - |
dc.date.available | 2021-12-01T07:52:40Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Viruses, 2021, v. 13 n. 11, article no. 2188 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308388 | - |
dc.description.abstract | In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and civets and genomic studies have confirmed bat-to-civet-to-human transmission. The MERS epidemic that emerged in 2012 had a ~35% mortality, with dromedaries as the reservoir. Although CoVs with the same genome organization (e.g., Tylonycteris BatCoV HKU4 and Pipistrellus BatCoV HKU5) were also detected in bats, there is still a phylogenetic gap between these bat CoVs and MERS-CoV. In 2016, 10 years after the discovery of Rhinolophus BatCoV HKU2 in Chinese horseshoe bats, fatal swine disease outbreaks caused by this virus were reported in southern China. In late 2019, an outbreak of pneumonia emerged in Wuhan, China, and rapidly spread globally, leading to >4,000,000 fatalities so far. Although the genome of SARS-CoV-2 is highly similar to that of SARS-CoV, patient zero and the original source of the pandemic are still unknown. To protect humans from future public health threats, measures should be taken to monitor and reduce the chance of interspecies jumping events, either occurring naturally or through recombineering experiments. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses | - |
dc.relation.ispartof | Viruses | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Interspecies jumping | - |
dc.subject | Bat | - |
dc.subject | Coronavirus | - |
dc.subject | Outbreak | - |
dc.subject | Epidemic | - |
dc.subject | Pandemic | - |
dc.subject | SARS | - |
dc.subject | MERS | - |
dc.subject | SADS | - |
dc.subject | COVID-19 | - |
dc.title | Interspecies Jumping of Bat Coronaviruses | - |
dc.type | Article | - |
dc.identifier.email | Wong, ACP: wcpanton@hku.hk | - |
dc.identifier.authority | Wong, ACP=rp02903 | - |
dc.identifier.authority | Lau, SKP=rp00486 | - |
dc.identifier.authority | Woo, PCY=rp00430 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/v13112188 | - |
dc.identifier.pmid | 34834994 | - |
dc.identifier.pmcid | PMC8620431 | - |
dc.identifier.scopus | eid_2-s2.0-85118375090 | - |
dc.identifier.hkuros | 330465 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. 2188 | - |
dc.identifier.epage | article no. 2188 | - |
dc.identifier.isi | WOS:000725543700001 | - |
dc.publisher.place | Switzerland | - |