File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice

TitleSex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice
Authors
Keywordslactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)
attention-deficit/hyperactivity disorder (ADHD)
insulin receptor (IR)
sex differences
electroencephalogram (EEG)
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/biomolecules
Citation
Biomolecules, 2021, v. 11 n. 12, p. article no. 1759 How to Cite?
AbstractA deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy, and metabolic abnormalities. Disruption of ganglioside production by this enzyme may also have a role in the development of neuropsychiatric disorders. ST3Gal5 knock-out (St3gal5−/−) mice lack a-, b- and c-series gangliosides, but exhibit no overt neuropathology, possibly owing to the production of compensatory 0-series glycosphingolipids. Here, we sought to investigate the possibility that St3gal5−/− mice might exhibit attention-deficit/hyperactivity disorder (ADHD)-like behaviours. In addition, we evaluated potential metabolic and electroencephalogram (EEG) abnormalities. St3gal5−/− mice were subjected to behavioural testing, glucose tolerance tests, and the levels of expression of brain and peripheral A and B isoforms of the insulin receptor (IR). We found that St3gal5−/− mice exhibit locomotor hyperactivity, impulsivity, neophobia, anxiety-like behaviour. The genotype also altered blood glucose levels and glucose tolerance. A sex bias was consistently found in relation to body mass and peripheral IR expression. Analysis of the EEG revealed an increase in amplitude in St3gal5−/− mice. Together, St3gal5−/− mice exhibit ADHD-like behaviours, altered metabolic and EEG measures providing a useful platform for better understanding of the contribution of brain gangliosides to ADHD and associated comorbidities.
Persistent Identifierhttp://hdl.handle.net/10722/308373
ISSN
2018 Impact Factor: 4.694
2020 SCImago Journal Rankings: 1.125

 

DC FieldValueLanguage
dc.contributor.authorStrekalova, T-
dc.contributor.authorVeniaminova, E-
dc.contributor.authorSvirin, E-
dc.contributor.authorKopeikina, E-
dc.contributor.authorVeremeyko, T-
dc.contributor.authorYung, AWY-
dc.contributor.authorProshin, A-
dc.contributor.authorTAN, SZK-
dc.contributor.authorKHAIRUDDIN, S-
dc.contributor.authorLim, LW-
dc.contributor.authorLesch, KP-
dc.contributor.authorWalitza, S-
dc.contributor.authorAnthony, DC-
dc.contributor.authorPonomarev, ED-
dc.date.accessioned2021-12-01T07:52:29Z-
dc.date.available2021-12-01T07:52:29Z-
dc.date.issued2021-
dc.identifier.citationBiomolecules, 2021, v. 11 n. 12, p. article no. 1759-
dc.identifier.issn2218-273X-
dc.identifier.urihttp://hdl.handle.net/10722/308373-
dc.description.abstractA deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy, and metabolic abnormalities. Disruption of ganglioside production by this enzyme may also have a role in the development of neuropsychiatric disorders. ST3Gal5 knock-out (St3gal5−/−) mice lack a-, b- and c-series gangliosides, but exhibit no overt neuropathology, possibly owing to the production of compensatory 0-series glycosphingolipids. Here, we sought to investigate the possibility that St3gal5−/− mice might exhibit attention-deficit/hyperactivity disorder (ADHD)-like behaviours. In addition, we evaluated potential metabolic and electroencephalogram (EEG) abnormalities. St3gal5−/− mice were subjected to behavioural testing, glucose tolerance tests, and the levels of expression of brain and peripheral A and B isoforms of the insulin receptor (IR). We found that St3gal5−/− mice exhibit locomotor hyperactivity, impulsivity, neophobia, anxiety-like behaviour. The genotype also altered blood glucose levels and glucose tolerance. A sex bias was consistently found in relation to body mass and peripheral IR expression. Analysis of the EEG revealed an increase in amplitude in St3gal5−/− mice. Together, St3gal5−/− mice exhibit ADHD-like behaviours, altered metabolic and EEG measures providing a useful platform for better understanding of the contribution of brain gangliosides to ADHD and associated comorbidities.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/biomolecules-
dc.relation.ispartofBiomolecules-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectlactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)-
dc.subjectattention-deficit/hyperactivity disorder (ADHD)-
dc.subjectinsulin receptor (IR)-
dc.subjectsex differences-
dc.subjectelectroencephalogram (EEG)-
dc.titleSex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/biom11121759-
dc.identifier.hkuros330534-
dc.identifier.volume11-
dc.identifier.issue12-
dc.identifier.spagearticle no. 1759-
dc.identifier.epagearticle no. 1759-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats