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- Publisher Website: 10.2340/00015555-3638
- Scopus: eid_2-s2.0-85096815480
- PMID: 32945341
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Article: Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis
Title | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
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Authors | |
Keywords | skin microbiome psoriasis skin status microbial diversity |
Issue Date | 2020 |
Publisher | Society for the Publication of Acta Dermato-Venereologica. The Journal's web site is located at http://www.medicaljournals.se/acta/index.php/ |
Citation | Acta Dermato-Venereologica, 2020, v. 100, p. article no. adv00329 How to Cite? |
Abstract | The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. |
Persistent Identifier | http://hdl.handle.net/10722/308295 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.015 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WANG, H | - |
dc.contributor.author | Chan, MWM | - |
dc.contributor.author | Chan, HH | - |
dc.contributor.author | Pang, H | - |
dc.date.accessioned | 2021-11-12T13:45:15Z | - |
dc.date.available | 2021-11-12T13:45:15Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Acta Dermato-Venereologica, 2020, v. 100, p. article no. adv00329 | - |
dc.identifier.issn | 0001-5555 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308295 | - |
dc.description.abstract | The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. | - |
dc.language | eng | - |
dc.publisher | Society for the Publication of Acta Dermato-Venereologica. The Journal's web site is located at http://www.medicaljournals.se/acta/index.php/ | - |
dc.relation.ispartof | Acta Dermato-Venereologica | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | skin microbiome | - |
dc.subject | psoriasis | - |
dc.subject | skin status | - |
dc.subject | microbial diversity | - |
dc.title | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis | - |
dc.type | Article | - |
dc.identifier.email | Chan, MWM: chanwmm@hku.hk | - |
dc.identifier.email | Chan, HH: hhlchan@hkucc.hku.hk | - |
dc.identifier.email | Pang, H: herbpang@hku.hk | - |
dc.identifier.authority | Chan, MWM=rp02394 | - |
dc.identifier.authority | Pang, H=rp01857 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.2340/00015555-3638 | - |
dc.identifier.pmid | 32945341 | - |
dc.identifier.scopus | eid_2-s2.0-85096815480 | - |
dc.identifier.hkuros | 330183 | - |
dc.identifier.volume | 100 | - |
dc.identifier.spage | article no. adv00329 | - |
dc.identifier.epage | article no. adv00329 | - |
dc.identifier.isi | WOS:000602623000027 | - |
dc.publisher.place | Sweden | - |