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- Publisher Website: 10.3390/ijms221810151
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- PMID: 34576314
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Article: Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease
Title | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
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Authors | |
Keywords | Stem cells Neurogenesis Alzheimer’s disease Stem cell therapy Neural stem cells Neurodegenerative disease Embryonic stem cells Mesenchymal stem cells Stem cell transplantation Induced pluripotent stem cells |
Issue Date | 2021 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2021, v. 22 n. 18, article no. 10151 How to Cite? |
Abstract | Alzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, but whether stem cells are safe and effective in humans is still not clear. In this narrative review, we discuss both preclinical studies and clinical trials on the therapeutic potential of human stem cells in AD. Preclinical studies have successfully differentiated stem cells into neurons in vitro, indicating the potential viability of stem cell therapy in neurodegenerative diseases. Preclinical studies have also shown that stem cell therapy is safe and effective in improving cognitive performance in animal models, as demonstrated in the Morris water maze test and novel object recognition test. Although few clinical trials have been completed and many trials are still in phase I and II, the initial results confirm the outcomes of the preclinical studies. However, limitations like rejection, tumorigenicity, and ethical issues are still barriers to the advancement of stem cell therapy. In conclusion, the use of stem cells in the treatment of AD shows promise in terms of effectiveness and safety. |
Persistent Identifier | http://hdl.handle.net/10722/308196 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, HJ | - |
dc.contributor.author | Yanshree | - |
dc.contributor.author | Roy, J | - |
dc.contributor.author | Tipoe, GL | - |
dc.contributor.author | Fung, ML | - |
dc.contributor.author | Lim, LW | - |
dc.date.accessioned | 2021-11-12T13:43:50Z | - |
dc.date.available | 2021-11-12T13:43:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2021, v. 22 n. 18, article no. 10151 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308196 | - |
dc.description.abstract | Alzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, but whether stem cells are safe and effective in humans is still not clear. In this narrative review, we discuss both preclinical studies and clinical trials on the therapeutic potential of human stem cells in AD. Preclinical studies have successfully differentiated stem cells into neurons in vitro, indicating the potential viability of stem cell therapy in neurodegenerative diseases. Preclinical studies have also shown that stem cell therapy is safe and effective in improving cognitive performance in animal models, as demonstrated in the Morris water maze test and novel object recognition test. Although few clinical trials have been completed and many trials are still in phase I and II, the initial results confirm the outcomes of the preclinical studies. However, limitations like rejection, tumorigenicity, and ethical issues are still barriers to the advancement of stem cell therapy. In conclusion, the use of stem cells in the treatment of AD shows promise in terms of effectiveness and safety. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Stem cells | - |
dc.subject | Neurogenesis | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Stem cell therapy | - |
dc.subject | Neural stem cells | - |
dc.subject | Neurodegenerative disease | - |
dc.subject | Embryonic stem cells | - |
dc.subject | Mesenchymal stem cells | - |
dc.subject | Stem cell transplantation | - |
dc.subject | Induced pluripotent stem cells | - |
dc.title | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease | - |
dc.type | Article | - |
dc.identifier.email | Tipoe, GL: tgeorge@hku.hk | - |
dc.identifier.email | Fung, ML: fungml@hku.hk | - |
dc.identifier.email | Lim, LW: limlw@hku.hk | - |
dc.identifier.authority | Tipoe, GL=rp00371 | - |
dc.identifier.authority | Fung, ML=rp00433 | - |
dc.identifier.authority | Lim, LW=rp02088 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms221810151 | - |
dc.identifier.pmid | 34576314 | - |
dc.identifier.pmcid | PMC8471075 | - |
dc.identifier.scopus | eid_2-s2.0-85115136664 | - |
dc.identifier.hkuros | 330350 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | article no. 10151 | - |
dc.identifier.epage | article no. 10151 | - |
dc.identifier.isi | WOS:000699732600001 | - |
dc.publisher.place | Switzerland | - |