File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Baicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes

TitleBaicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes
Authors
Keywordsbaicalein
biofilm
dental caries
hydrophobicity
hydroxyflavone
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antibiotics
Citation
Antibiotics, 2021, v. 10 n. 2, p. article no. 215 How to Cite?
AbstractDental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in Streptococcus mutans. Baicalein significantly inhibited biofilm formation by Streptococcus mutans UA159 (MBIC50 = 200 μM), without significant growth inhibition. Notably, these concentrations of baicalein did not affect the commensal S. gordonii. Strikingly, baicalein significantly reduced cell surface hydrophobicity, autoaggregation and acid production by S. mutans. Mechanistic studies (qRT-PCR) showed downregulation of various genes regulating biofilm formation, surface attachment, quorum sensing, acid production and competence. Finally, we demonstrate the potential translational value of baicalein by reporting synergistic interaction with fluoride against S. mutans biofilms.
Persistent Identifierhttp://hdl.handle.net/10722/308060
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 0.920
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVijayakumar, A-
dc.contributor.authorSarveswari, HB-
dc.contributor.authorVasudevan, S-
dc.contributor.authorShanmugam, K-
dc.contributor.authorSolomon, AP-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-11-12T13:41:56Z-
dc.date.available2021-11-12T13:41:56Z-
dc.date.issued2021-
dc.identifier.citationAntibiotics, 2021, v. 10 n. 2, p. article no. 215-
dc.identifier.issn2079-6382-
dc.identifier.urihttp://hdl.handle.net/10722/308060-
dc.description.abstractDental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in Streptococcus mutans. Baicalein significantly inhibited biofilm formation by Streptococcus mutans UA159 (MBIC50 = 200 μM), without significant growth inhibition. Notably, these concentrations of baicalein did not affect the commensal S. gordonii. Strikingly, baicalein significantly reduced cell surface hydrophobicity, autoaggregation and acid production by S. mutans. Mechanistic studies (qRT-PCR) showed downregulation of various genes regulating biofilm formation, surface attachment, quorum sensing, acid production and competence. Finally, we demonstrate the potential translational value of baicalein by reporting synergistic interaction with fluoride against S. mutans biofilms.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antibiotics-
dc.relation.ispartofAntibiotics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbaicalein-
dc.subjectbiofilm-
dc.subjectdental caries-
dc.subjecthydrophobicity-
dc.subjecthydroxyflavone-
dc.titleBaicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/antibiotics10020215-
dc.identifier.pmid33670013-
dc.identifier.pmcidPMC7926557-
dc.identifier.scopuseid_2-s2.0-85102105159-
dc.identifier.hkuros330318-
dc.identifier.volume10-
dc.identifier.issue2-
dc.identifier.spagearticle no. 215-
dc.identifier.epagearticle no. 215-
dc.identifier.isiWOS:000622017700001-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats