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Article: Trans-Cinnamaldehyde Attenuates Enterococcus faecalis Virulence and Inhibits Biofilm Formation

TitleTrans-Cinnamaldehyde Attenuates Enterococcus faecalis Virulence and Inhibits Biofilm Formation
Authors
Keywordsbiofilms
Enterococcus faecalis
quorum sensing
trans-cinnamaldehyde
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antibiotics
Citation
Antibiotics, 2021, v. 10 n. 6, p. article no. 702 How to Cite?
AbstractEnterococcus faecalis as an important nosocomial pathogen is critically implicated in the pathogenesis of endocarditis, urinary tract, and persistent root canal infections. Its major virulence attributes (biofilm formation, production of proteases, and hemolytic toxins) enable it to cause extensive host tissue damage. With the alarming increase in enterococcal resistance to antibiotics, novel therapeutics are required to inhibit E. faecalis biofilm formation and virulence. Trans-cinnamaldehyde (TC), the main phytochemical in cinnamon essential oils, has demonstrated promising activity against a wide range of pathogens. Here, we comprehensively investigated the effect of TC on planktonic growth, biofilm formation, proteolytic and hemolytic activities, as well as gene regulation in E. faecalis. Our findings revealed that sub-inhibitory concentrations of TC reduced biofilm formation, biofilm exopolysaccharides, as well as its proteolytic and hemolytic activities. Mechanistic studies revealed significant downregulation of the quorum sensing fsr locus and downstream gelE, which are major virulence regulators in E. faecalis. Taken together, our study highlights the potential of TC to inhibit E. faecalis biofilm formation and its virulence.
Persistent Identifierhttp://hdl.handle.net/10722/308055
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 0.920
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorALI, IAA-
dc.contributor.authorMatinlinna, JP-
dc.contributor.authorLévesque, CM-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-11-12T13:41:52Z-
dc.date.available2021-11-12T13:41:52Z-
dc.date.issued2021-
dc.identifier.citationAntibiotics, 2021, v. 10 n. 6, p. article no. 702-
dc.identifier.issn2079-6382-
dc.identifier.urihttp://hdl.handle.net/10722/308055-
dc.description.abstractEnterococcus faecalis as an important nosocomial pathogen is critically implicated in the pathogenesis of endocarditis, urinary tract, and persistent root canal infections. Its major virulence attributes (biofilm formation, production of proteases, and hemolytic toxins) enable it to cause extensive host tissue damage. With the alarming increase in enterococcal resistance to antibiotics, novel therapeutics are required to inhibit E. faecalis biofilm formation and virulence. Trans-cinnamaldehyde (TC), the main phytochemical in cinnamon essential oils, has demonstrated promising activity against a wide range of pathogens. Here, we comprehensively investigated the effect of TC on planktonic growth, biofilm formation, proteolytic and hemolytic activities, as well as gene regulation in E. faecalis. Our findings revealed that sub-inhibitory concentrations of TC reduced biofilm formation, biofilm exopolysaccharides, as well as its proteolytic and hemolytic activities. Mechanistic studies revealed significant downregulation of the quorum sensing fsr locus and downstream gelE, which are major virulence regulators in E. faecalis. Taken together, our study highlights the potential of TC to inhibit E. faecalis biofilm formation and its virulence.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antibiotics-
dc.relation.ispartofAntibiotics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbiofilms-
dc.subjectEnterococcus faecalis-
dc.subjectquorum sensing-
dc.subjecttrans-cinnamaldehyde-
dc.titleTrans-Cinnamaldehyde Attenuates Enterococcus faecalis Virulence and Inhibits Biofilm Formation-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/antibiotics10060702-
dc.identifier.pmid34208134-
dc.identifier.pmcidPMC8230787-
dc.identifier.scopuseid_2-s2.0-85108590500-
dc.identifier.hkuros329542-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spagearticle no. 702-
dc.identifier.epagearticle no. 702-
dc.identifier.isiWOS:000665557600001-
dc.publisher.placeSwitzerland-

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