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Article: The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

TitleThe role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
Authors
KeywordsAMR
epidemiology
genetics
genomics
infectious disease
Issue Date2021
PublishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/
Citation
eLife, 2021, v. 10, p. article no. e67113 How to Cite?
AbstractMultidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1-type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-β-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
Persistent Identifierhttp://hdl.handle.net/10722/307907
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 3.932
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorD'Aeth, JC-
dc.contributor.authorvan der linden, MPG-
dc.contributor.authorMcGee, L-
dc.contributor.authorde Lencastre, H-
dc.contributor.authorTurner, P-
dc.contributor.authorSong, JH-
dc.contributor.authorLo, SW-
dc.contributor.authorGladstone, RA-
dc.contributor.authorSá-Leão, R-
dc.contributor.authorKo, KS-
dc.contributor.authorHange, WP-
dc.contributor.authorBreiman, RF-
dc.contributor.authorBeall, B-
dc.contributor.authorBentley, SD-
dc.contributor.authorCroucher, NJ-
dc.contributor.authorCorso, A-
dc.contributor.authorFaccone, D-
dc.contributor.authorGagetti, P-
dc.contributor.authorBrooks, AW-
dc.contributor.authorHasanuzzaman, M-
dc.contributor.authorMalaker, R-
dc.contributor.authorSaha, SK-
dc.contributor.authorDavydov, A-
dc.contributor.authorTitov, L-
dc.contributor.authorde Cunto Brandileone, MC-
dc.contributor.authorAlmeida, ACG-
dc.contributor.authorIP, M-
dc.contributor.authorHo, PL-
dc.contributor.authorLAW, YT-
dc.contributor.authorZHAO, C-
dc.contributor.authorWANG, H-
dc.contributor.authorKeenaN, J-
dc.contributor.authorSampane-Donkor, R-
dc.contributor.authorVeeraraghavan, B-
dc.contributor.authorNagaraj, G-
dc.contributor.authorRavikumar, KL-
dc.contributor.authorGivon-Lavi, N-
dc.contributor.authorPorat, N-
dc.contributor.authorBenisty, R-
dc.contributor.authorDagan, R-
dc.contributor.authorBigogo, G-
dc.contributor.authorVerani, J-
dc.contributor.authorKiran, A-
dc.contributor.authorEverett, DB-
dc.contributor.authorCornick, J-
dc.contributor.authorAlaerts, M-
dc.contributor.authorSekaran, SD-
dc.contributor.authorClarke, SC-
dc.contributor.authorBelabbès, H-
dc.contributor.authorDiawara, I-
dc.contributor.authorZeroualI, K-
dc.contributor.authorElmdaghri, N-
dc.contributor.authorMoiane, B-
dc.contributor.authorSigauque, B-
dc.contributor.authorMucavele, H-
dc.contributor.authorPollard, AJ-
dc.contributor.authorKandasamy, R-
dc.contributor.authorCarter, PE-
dc.contributor.authorObaro, S-
dc.contributor.authorShakoor, S-
dc.contributor.authorLehmann, D-
dc.contributor.authorFord, R-
dc.contributor.authorOchoa, TJ-
dc.contributor.authorSkoczynska, A-
dc.contributor.authorSadowy, E-
dc.contributor.authorHryniewicz, W-
dc.contributor.authorDoiphode, S-
dc.contributor.authorEgorova, E-
dc.contributor.authorVoropaeva, E-
dc.contributor.authorUrban, Y-
dc.contributor.authorParagi, M-
dc.contributor.authorKastrin, T-
dc.contributor.authorVon Gottberg, A-
dc.contributor.authorNdlangisa, KM-
dc.contributor.authorDe Gouveia, L-
dc.contributor.authorDu Plessis, M-
dc.contributor.authorAli, M-
dc.contributor.authorWolter, N-
dc.contributor.authorMadhi, SA-
dc.contributor.authorNzenze, SA-
dc.contributor.authorSrifuengfung, S-
dc.contributor.authorKwambana-Adams, B-
dc.contributor.authorFoster-Nyarko, E-
dc.contributor.authorBojang, E-
dc.contributor.authorAntonio, M-
dc.contributor.authorTientcheu, PE-
dc.contributor.authorMoïsi, J-
dc.contributor.authorNurse-Lucas, M-
dc.contributor.authorAkpaka, PE-
dc.contributor.authorEser, OK-
dc.contributor.authorMaguire, A-
dc.contributor.authorAanensen, D-
dc.contributor.authorBentley, L-
dc.contributor.authorBhai, JNNT-
dc.contributor.authorMostowy, R-
dc.contributor.authorLees, JA-
dc.contributor.authorKlugman, KP-
dc.contributor.authorHawkins, P-
dc.contributor.authorCleary, D-
dc.date.accessioned2021-11-12T13:39:38Z-
dc.date.available2021-11-12T13:39:38Z-
dc.date.issued2021-
dc.identifier.citationeLife, 2021, v. 10, p. article no. e67113-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10722/307907-
dc.description.abstractMultidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1-type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-β-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.-
dc.languageeng-
dc.publishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/-
dc.relation.ispartofeLife-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAMR-
dc.subjectepidemiology-
dc.subjectgenetics-
dc.subjectgenomics-
dc.subjectinfectious disease-
dc.titleThe role of interspecies recombination in the evolution of antibiotic-resistant pneumococci-
dc.typeArticle-
dc.identifier.emailHo, PL: plho@hku.hk-
dc.identifier.authorityHo, PL=rp00406-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7554/eLife.67113-
dc.identifier.pmid34259624-
dc.identifier.pmcidPMC8321556-
dc.identifier.scopuseid_2-s2.0-85111441023-
dc.identifier.hkuros329804-
dc.identifier.volume10-
dc.identifier.spagearticle no. e67113-
dc.identifier.epagearticle no. e67113-
dc.identifier.isiWOS:000680059100001-
dc.publisher.placeCambridge, UK-

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