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Article: Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group

TitleTreatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
Authors
KeywordsMantle cell lymphoma
Asia
Treatment
Guidelines
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org
Citation
Journal of Hematology & Oncology, 2020, v. 13 n. 1, p. article no. 21 How to Cite?
AbstractBackground: Mantle cell lymphoma (MCL) is a B cell malignancy that can be aggressive and with a poor prognosis; the clinical course is heterogeneous. The epidemiology of MCL in Asia is not well documented but appears to comprise 2–6% of all lymphoma cases based on available data, with variation observed between countries. Although international guidelines are available for the treatment of MCL, there is a lack of published data or guidance on the clinical characteristics and management of MCL in patient populations from Asia. This paper aims to review the available treatment and, where clinical gaps exist, provide expert consensus from the Asian Lymphoma Study Group (ALSG) on appropriate MCL management in Asia. Body: Management strategies for MCL are patient- and disease stage-specific and aim to achieve balance between efficacy outcomes and toxicity. For asymptomatic patients with clearly indolent disease, observation may be an appropriate strategy. For stage I/II disease, following international guidelines is appropriate, which include either a short course of conventional chemotherapy followed by consolidated radiotherapy, less aggressive chemotherapy regimens, or a combination of these approaches. For advanced disease, the approach is based on the age and fitness of the patient. For young, fit patients, the current practice for induction therapy differs across Asia, with cytarabine having an important role in this setting. Hematopoietic stem cell transplantation (HSCT) may be justified in selected patients because of the high relapse risk. In elderly patients, specific chemoimmunotherapy regimens available in each country/region are a treatment option. For maintenance therapy after first-line treatment, the choice of approach should be individualized, with cost being an important consideration within Asia. For relapsed/refractory disease, ibrutinib should be considered as well as other follow-on compounds, if available. Conclusion: Asian patient-specific data for the treatment of MCL are lacking, and the availability of treatment options differs between country/region within Asia. Therefore, there is no clear one-size-fits-all approach and further investigation on the most appropriate sequence of treatment that should be considered for this heterogeneous disease.
Persistent Identifierhttp://hdl.handle.net/10722/307898
ISSN
2018 Impact Factor: 8.731
2020 SCImago Journal Rankings: 4.305
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoon, DH-
dc.contributor.authorCao, J-
dc.contributor.authorChen, TY-
dc.contributor.authorIzutsu, K-
dc.contributor.authorKim, SJ-
dc.contributor.authorKwong, YL-
dc.contributor.authorLin, TY-
dc.contributor.authorThye, LS-
dc.contributor.authorXu, B-
dc.contributor.authorYang, DH-
dc.contributor.authorKim, WS-
dc.date.accessioned2021-11-12T13:39:30Z-
dc.date.available2021-11-12T13:39:30Z-
dc.date.issued2020-
dc.identifier.citationJournal of Hematology & Oncology, 2020, v. 13 n. 1, p. article no. 21-
dc.identifier.issn1756-8722-
dc.identifier.urihttp://hdl.handle.net/10722/307898-
dc.description.abstractBackground: Mantle cell lymphoma (MCL) is a B cell malignancy that can be aggressive and with a poor prognosis; the clinical course is heterogeneous. The epidemiology of MCL in Asia is not well documented but appears to comprise 2–6% of all lymphoma cases based on available data, with variation observed between countries. Although international guidelines are available for the treatment of MCL, there is a lack of published data or guidance on the clinical characteristics and management of MCL in patient populations from Asia. This paper aims to review the available treatment and, where clinical gaps exist, provide expert consensus from the Asian Lymphoma Study Group (ALSG) on appropriate MCL management in Asia. Body: Management strategies for MCL are patient- and disease stage-specific and aim to achieve balance between efficacy outcomes and toxicity. For asymptomatic patients with clearly indolent disease, observation may be an appropriate strategy. For stage I/II disease, following international guidelines is appropriate, which include either a short course of conventional chemotherapy followed by consolidated radiotherapy, less aggressive chemotherapy regimens, or a combination of these approaches. For advanced disease, the approach is based on the age and fitness of the patient. For young, fit patients, the current practice for induction therapy differs across Asia, with cytarabine having an important role in this setting. Hematopoietic stem cell transplantation (HSCT) may be justified in selected patients because of the high relapse risk. In elderly patients, specific chemoimmunotherapy regimens available in each country/region are a treatment option. For maintenance therapy after first-line treatment, the choice of approach should be individualized, with cost being an important consideration within Asia. For relapsed/refractory disease, ibrutinib should be considered as well as other follow-on compounds, if available. Conclusion: Asian patient-specific data for the treatment of MCL are lacking, and the availability of treatment options differs between country/region within Asia. Therefore, there is no clear one-size-fits-all approach and further investigation on the most appropriate sequence of treatment that should be considered for this heterogeneous disease.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org-
dc.relation.ispartofJournal of Hematology & Oncology-
dc.rightsJournal of Hematology & Oncology. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMantle cell lymphoma-
dc.subjectAsia-
dc.subjectTreatment-
dc.subjectGuidelines-
dc.titleTreatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group-
dc.typeArticle-
dc.identifier.emailKwong, YL: ylkwong@hkucc.hku.hk-
dc.identifier.authorityKwong, YL=rp00358-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-020-00855-9-
dc.identifier.pmid32183871-
dc.identifier.pmcidPMC7079508-
dc.identifier.hkuros329963-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spagearticle no. 21-
dc.identifier.epagearticle no. 21-
dc.identifier.isiWOS:000521236100001-
dc.publisher.placeUnited Kingdom-

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