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Article: Exploring the anti-caries properties of baicalin against Streptococcus mutans: an in vitro study

TitleExploring the anti-caries properties of baicalin against Streptococcus mutans: an in vitro study
Authors
KeywordsBaicalin
biofilm
dental caries
streptococcus mutans
virulence
Issue Date2021
PublisherTaylor & Francis: STM journals. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08927014.asp
Citation
Biofouling, 2021, v. 37 n. 3, p. 267-275 How to Cite?
AbstractPlant-derived molecules are excellent alternatives to antibiotics as anti-infective agents owing to their minimal cytotoxicity. Herein, the anti-infective property of the hydroxyflavone baicalin, was investigated against biofilms of the key dental caries pathogen Streptococcus mutans. Baicalin inhibited sucrose-dependent biofilm formation at a concentration of 500 µg ml−1 without affecting bacterial growth. It significantly inhibited acid production for an extended period of 8 h. Microscopic analysis revealed a 6-fold reduction in the number of adhered cells with baicalin treatment. Transcriptomic analysis of the mid-log phase and biofilm cells showed marked downregulation of the virulence genes required for biofilm formation and acid production. This study sheds significant new light on the potential for baicalin to be developed into an anti-caries agent.
Persistent Identifierhttp://hdl.handle.net/10722/307835
ISSN
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.518
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorElango, AV-
dc.contributor.authorVasudevan, S-
dc.contributor.authorShanmugam, K-
dc.contributor.authorSolomon, AP-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-11-12T13:38:36Z-
dc.date.available2021-11-12T13:38:36Z-
dc.date.issued2021-
dc.identifier.citationBiofouling, 2021, v. 37 n. 3, p. 267-275-
dc.identifier.issn0892-7014-
dc.identifier.urihttp://hdl.handle.net/10722/307835-
dc.description.abstractPlant-derived molecules are excellent alternatives to antibiotics as anti-infective agents owing to their minimal cytotoxicity. Herein, the anti-infective property of the hydroxyflavone baicalin, was investigated against biofilms of the key dental caries pathogen Streptococcus mutans. Baicalin inhibited sucrose-dependent biofilm formation at a concentration of 500 µg ml−1 without affecting bacterial growth. It significantly inhibited acid production for an extended period of 8 h. Microscopic analysis revealed a 6-fold reduction in the number of adhered cells with baicalin treatment. Transcriptomic analysis of the mid-log phase and biofilm cells showed marked downregulation of the virulence genes required for biofilm formation and acid production. This study sheds significant new light on the potential for baicalin to be developed into an anti-caries agent.-
dc.languageeng-
dc.publisherTaylor & Francis: STM journals. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08927014.asp-
dc.relation.ispartofBiofouling-
dc.rightsAccepted Manuscript (AM) i.e. Postprint This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI].-
dc.subjectBaicalin-
dc.subjectbiofilm-
dc.subjectdental caries-
dc.subjectstreptococcus mutans-
dc.subjectvirulence-
dc.titleExploring the anti-caries properties of baicalin against Streptococcus mutans: an in vitro study-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/08927014.2021.1897789-
dc.identifier.pmid33719751-
dc.identifier.scopuseid_2-s2.0-85102444791-
dc.identifier.hkuros329687-
dc.identifier.volume37-
dc.identifier.issue3-
dc.identifier.spage267-
dc.identifier.epage275-
dc.identifier.isiWOS:000627180400001-
dc.publisher.placeUnited Kingdom-

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