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- Publisher Website: 10.3390/cells10082153
- Scopus: eid_2-s2.0-85115041749
- PMID: 34440922
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Article: Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa
Title | Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa |
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Authors | |
Keywords | eye homeostasis ocular stress regulated cell death retina |
Issue Date | 2021 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells |
Citation | Cells, 2021, v. 10 n. 8, p. article no. 2153 How to Cite? |
Abstract | Retinitis pigmentosa (RP) is a leading cause of inherited retinal degeneration, with more than 60 gene mutations. Despite the genetic heterogenicity, photoreceptor cell damage remains the hallmark of RP pathology. As a result, RP patients usually suffer from reduced night vision, loss of peripheral vision, decreased visual acuity, and impaired color perception. Although photoreceptor cell death is the primary outcome of RP, the underlying mechanisms are not completely elucidated. Ferroptosis is a novel programmed cell death, with characteristic iron overload and lipid peroxidation. Recent studies, using in vitro and in vivo RP models, discovered the involvement of ferroptosis-associated cell death, suggesting a possible new mechanism for RP pathogenesis. In this review, we discuss the association between ferroptosis and photoreceptor cell damage, and its implication in the pathogenesis of RP. We propose that ferroptotic cell death not only opens up a new research area in RP, but may also serve as a novel therapeutic target for RP. |
Persistent Identifier | http://hdl.handle.net/10722/307818 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.547 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | YANG, M | - |
dc.contributor.author | So, KF | - |
dc.contributor.author | Lam, WC | - |
dc.contributor.author | Lo, ACY | - |
dc.date.accessioned | 2021-11-12T13:38:21Z | - |
dc.date.available | 2021-11-12T13:38:21Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Cells, 2021, v. 10 n. 8, p. article no. 2153 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307818 | - |
dc.description.abstract | Retinitis pigmentosa (RP) is a leading cause of inherited retinal degeneration, with more than 60 gene mutations. Despite the genetic heterogenicity, photoreceptor cell damage remains the hallmark of RP pathology. As a result, RP patients usually suffer from reduced night vision, loss of peripheral vision, decreased visual acuity, and impaired color perception. Although photoreceptor cell death is the primary outcome of RP, the underlying mechanisms are not completely elucidated. Ferroptosis is a novel programmed cell death, with characteristic iron overload and lipid peroxidation. Recent studies, using in vitro and in vivo RP models, discovered the involvement of ferroptosis-associated cell death, suggesting a possible new mechanism for RP pathogenesis. In this review, we discuss the association between ferroptosis and photoreceptor cell damage, and its implication in the pathogenesis of RP. We propose that ferroptotic cell death not only opens up a new research area in RP, but may also serve as a novel therapeutic target for RP. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells | - |
dc.relation.ispartof | Cells | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | eye | - |
dc.subject | homeostasis | - |
dc.subject | ocular stress | - |
dc.subject | regulated cell death | - |
dc.subject | retina | - |
dc.title | Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa | - |
dc.type | Article | - |
dc.identifier.email | So, KF: hrmaskf@hku.hk | - |
dc.identifier.email | Lam, WC: waichlam@hku.hk | - |
dc.identifier.email | Lo, ACY: amylo@hku.hk | - |
dc.identifier.authority | So, KF=rp00329 | - |
dc.identifier.authority | Lam, WC=rp02162 | - |
dc.identifier.authority | Lo, ACY=rp00425 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/cells10082153 | - |
dc.identifier.pmid | 34440922 | - |
dc.identifier.pmcid | PMC8393369 | - |
dc.identifier.scopus | eid_2-s2.0-85115041749 | - |
dc.identifier.hkuros | 329667 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | article no. 2153 | - |
dc.identifier.epage | article no. 2153 | - |
dc.identifier.isi | WOS:000688913400001 | - |
dc.publisher.place | Switzerland | - |