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- PMID: 33931128
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Article: Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets
Title | Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets |
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Authors | |
Keywords | Diabetic retinopathy Neurovascular unit Neurodegeneration Gliosis Inflammation Treatment |
Issue Date | 2021 |
Publisher | BioMed Central Ltd. The Journal's web site is located at https://eandv.biomedcentral.com/ |
Citation | Eye and Vision, 2021, v. 8, article no. 15 How to Cite? |
Abstract | Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regarded as a purely microvascular disease in the retina. However, an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina. Deterioration of neural retina could precede microvascular abnormalities in the DR, leading to microvascular changes. Furthermore, disruption of interactions among neurons, vascular cells, glia and local immune cells, which collectively form the neurovascular unit, is considered to be associated with the progression of DR early on in the disease. Therefore, it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration, neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage DR. Here, we present current perspectives on the pathophysiology of DR as a neurovascular disease, especially at the early stage. Potential novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well. |
Persistent Identifier | http://hdl.handle.net/10722/307600 |
ISSN | 2023 Impact Factor: 4.1 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Nian, S | - |
dc.contributor.author | Lo, ACY | - |
dc.contributor.author | Mi, Y | - |
dc.contributor.author | Ren, K | - |
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2021-11-12T13:34:58Z | - |
dc.date.available | 2021-11-12T13:34:58Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Eye and Vision, 2021, v. 8, article no. 15 | - |
dc.identifier.issn | 2326-0246 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307600 | - |
dc.description.abstract | Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regarded as a purely microvascular disease in the retina. However, an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina. Deterioration of neural retina could precede microvascular abnormalities in the DR, leading to microvascular changes. Furthermore, disruption of interactions among neurons, vascular cells, glia and local immune cells, which collectively form the neurovascular unit, is considered to be associated with the progression of DR early on in the disease. Therefore, it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration, neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage DR. Here, we present current perspectives on the pathophysiology of DR as a neurovascular disease, especially at the early stage. Potential novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at https://eandv.biomedcentral.com/ | - |
dc.relation.ispartof | Eye and Vision | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Diabetic retinopathy | - |
dc.subject | Neurovascular unit | - |
dc.subject | Neurodegeneration | - |
dc.subject | Gliosis | - |
dc.subject | Inflammation | - |
dc.subject | Treatment | - |
dc.title | Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets | - |
dc.type | Article | - |
dc.identifier.email | Lo, ACY: amylo@hku.hk | - |
dc.identifier.authority | Lo, ACY=rp00425 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s40662-021-00239-1 | - |
dc.identifier.pmid | 33931128 | - |
dc.identifier.pmcid | PMC8088070 | - |
dc.identifier.hkuros | 329665 | - |
dc.identifier.volume | 8 | - |
dc.identifier.spage | article no. 15 | - |
dc.identifier.epage | article no. 15 | - |
dc.identifier.isi | WOS:000645908000002 | - |
dc.publisher.place | United Kingdom | - |