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Article: Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients

TitlePrimary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients
Authors
Keywordscentral nervous system
outcome
post-transplant lymphoproliferative disorder
transplant
treatment
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal of Haematology, 2021, v. 193 n. 6, p. 1178-1184 How to Cite?
AbstractPrimary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin’s Lymphoma and/or international Berlin–Frankfurt–Münster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 ≥ 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four-year event-free and overall survival rates were 50% ± 10% and 74% ± 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration.
Persistent Identifierhttp://hdl.handle.net/10722/306881
ISSN
2020 Impact Factor: 6.998
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTaj, MM-
dc.contributor.authorMaecker-Kolhoff, B-
dc.contributor.authorLing, R-
dc.contributor.authorBomken, S-
dc.contributor.authorBurkhardt, B-
dc.contributor.authorChiang, AKS-
dc.contributor.authorCsoka, M-
dc.contributor.authorFüreder, A-
dc.contributor.authorHaouy, S-
dc.contributor.authorLazic, J-
dc.contributor.authorMiakova, N-
dc.contributor.authorMinard-Colin, V-
dc.contributor.authorTurner, SD-
dc.contributor.authorUyttebroeck, A-
dc.contributor.authorAttarbaschi, A-
dc.date.accessioned2021-10-22T07:40:57Z-
dc.date.available2021-10-22T07:40:57Z-
dc.date.issued2021-
dc.identifier.citationBritish Journal of Haematology, 2021, v. 193 n. 6, p. 1178-1184-
dc.identifier.issn0007-1048-
dc.identifier.urihttp://hdl.handle.net/10722/306881-
dc.description.abstractPrimary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin’s Lymphoma and/or international Berlin–Frankfurt–Münster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 ≥ 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four-year event-free and overall survival rates were 50% ± 10% and 74% ± 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH-
dc.relation.ispartofBritish Journal of Haematology-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcentral nervous system-
dc.subjectoutcome-
dc.subjectpost-transplant lymphoproliferative disorder-
dc.subjecttransplant-
dc.subjecttreatment-
dc.titlePrimary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients-
dc.typeArticle-
dc.identifier.emailChiang, AKS: chiangak@hku.hk-
dc.identifier.authorityChiang, AKS=rp00403-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/bjh.17398-
dc.identifier.pmid33764500-
dc.identifier.scopuseid_2-s2.0-85103213212-
dc.identifier.hkuros328945-
dc.identifier.volume193-
dc.identifier.issue6-
dc.identifier.spage1178-
dc.identifier.epage1184-
dc.identifier.isiWOS:000632527800001-
dc.publisher.placeUnited Kingdom-

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