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Article: Immunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus

TitleImmunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus
Authors
KeywordsAutoimmune disease
systemic lupus erythematosus (SLE)
mesenchymal stem cells (MSCs)
Issue Date2020
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2020, v. 29 n. 8, p. 872-883 How to Cite?
AbstractMesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex–histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this study. MRL/lpr mice which can develop acquired SLE-like phenotypes were selected as an animal model. Mesenchymal stem cells obtained from green fluorescent protein-transgenic ICR mice were infused into MRL/lpr mice at either the early or late stage of disease. The dosage was 1 × 106/mice per infusion. Mice were stratified into six groups including negative controls and those receiving one, two, three, four or five doses at 2-weekly intervals. The phenotypes were monitored regularly. After treatment, the spleen CD3+CD4–CD8– T and CD19+ B cells of two-dose mesenchymal stem cell-treated mice were significantly lower than those of the phosphate-buffered saline control. In terms of reducing the severity of SLE such as hair loss, skin ulcers, proteinuria and anti-dsDNA level, mesenchymal stem cells given at the early stage responded better and mice receiving two doses of mesenchymal stem cells performed better than those receiving either a lower dose (one dose) or higher doses (three, four or five doses). In conclusion, early treatment and an optimal dose of mesenchymal stem cells can effectively suppress the murine SLE model.
Persistent Identifierhttp://hdl.handle.net/10722/306879
ISSN
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.812
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, F-
dc.contributor.authorChen, H-
dc.contributor.authorChen, T-
dc.contributor.authorLau, CS-
dc.contributor.authorYu, FX-
dc.contributor.authorChen, K-
dc.contributor.authorChen, HP-
dc.contributor.authorPan, RS-
dc.contributor.authorChan, GCF-
dc.contributor.authorZhang, XY-
dc.contributor.authorNie, YJ-
dc.date.accessioned2021-10-22T07:40:55Z-
dc.date.available2021-10-22T07:40:55Z-
dc.date.issued2020-
dc.identifier.citationLupus, 2020, v. 29 n. 8, p. 872-883-
dc.identifier.issn0961-2033-
dc.identifier.urihttp://hdl.handle.net/10722/306879-
dc.description.abstractMesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex–histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this study. MRL/lpr mice which can develop acquired SLE-like phenotypes were selected as an animal model. Mesenchymal stem cells obtained from green fluorescent protein-transgenic ICR mice were infused into MRL/lpr mice at either the early or late stage of disease. The dosage was 1 × 106/mice per infusion. Mice were stratified into six groups including negative controls and those receiving one, two, three, four or five doses at 2-weekly intervals. The phenotypes were monitored regularly. After treatment, the spleen CD3+CD4–CD8– T and CD19+ B cells of two-dose mesenchymal stem cell-treated mice were significantly lower than those of the phosphate-buffered saline control. In terms of reducing the severity of SLE such as hair loss, skin ulcers, proteinuria and anti-dsDNA level, mesenchymal stem cells given at the early stage responded better and mice receiving two doses of mesenchymal stem cells performed better than those receiving either a lower dose (one dose) or higher doses (three, four or five doses). In conclusion, early treatment and an optimal dose of mesenchymal stem cells can effectively suppress the murine SLE model.-
dc.languageeng-
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com-
dc.relation.ispartofLupus-
dc.rightsAuthor(s), Contribution Title, Journal Title (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). DOI: [DOI number].-
dc.subjectAutoimmune disease-
dc.subjectsystemic lupus erythematosus (SLE)-
dc.subjectmesenchymal stem cells (MSCs)-
dc.titleImmunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus-
dc.typeArticle-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.authorityLau, CS=rp01348-
dc.identifier.authorityChan, GCF=rp00431-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0961203320928419-
dc.identifier.pmid32580680-
dc.identifier.scopuseid_2-s2.0-85086835367-
dc.identifier.hkuros328472-
dc.identifier.volume29-
dc.identifier.issue8-
dc.identifier.spage872-
dc.identifier.epage883-
dc.identifier.isiWOS:000543439500007-
dc.publisher.placeUnited Kingdom-

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