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Article: Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord

TitleAdiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord
Authors
KeywordsAdiponectin
AdipoR
AMPK
electroacupuncture
acupuncture analgesia
Issue Date2022
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi
Citation
Brain, Behavior, and Immunity, 2022, v. 99, p. 43-52 How to Cite?
AbstractNeurotransmitter-mediated acupuncture analgesia has been widely studied in nervous systems. It remains largely unclear if peripheral substances are involved the acupuncture analgesia. Adiponectin (APN), a circulating adipokine, shows analgesic effects. The study aimed to examine whether APN regulates analgesic effects of electroacupuncture (EA) in the complete Freund’s adjuvant (CFA)-induced mouse model. APN wild type (WT) and knockout (KO) mouse were employed in the study. We found that EA attenuates the CFA-induced pain as demonstrated by the Hargreaves thermal test and the von Frey filament test. The deletion of APN significantly reduced the acupuncture analgesia in the CFA-treated APN KO mice while the intrathecal administration of APN mimicked the analgesic effects of EA. We further revealed that EA produced analgesic effects mainly via APN/AdipoR2-mediated AMPK pathway by the siRNA inhibitions of APN receptors (adipoR1/2) in the spinal cord. The immunofluorescence staining analysis showed that EA increased the APN accumulation in spinal cord through the blood circulation. In conclusion, the study indicates a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMPK pathway in the spinal cord.
Persistent Identifierhttp://hdl.handle.net/10722/306481
ISSN
2023 Impact Factor: 8.8
2023 SCImago Journal Rankings: 3.141
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNing, Z-
dc.contributor.authorGU, P-
dc.contributor.authorZHANG, J-
dc.contributor.authorCheung, CW-
dc.contributor.authorLao, L-
dc.contributor.authorChen, H-
dc.contributor.authorZhang, ZJ-
dc.date.accessioned2021-10-22T07:35:14Z-
dc.date.available2021-10-22T07:35:14Z-
dc.date.issued2022-
dc.identifier.citationBrain, Behavior, and Immunity, 2022, v. 99, p. 43-52-
dc.identifier.issn0889-1591-
dc.identifier.urihttp://hdl.handle.net/10722/306481-
dc.description.abstractNeurotransmitter-mediated acupuncture analgesia has been widely studied in nervous systems. It remains largely unclear if peripheral substances are involved the acupuncture analgesia. Adiponectin (APN), a circulating adipokine, shows analgesic effects. The study aimed to examine whether APN regulates analgesic effects of electroacupuncture (EA) in the complete Freund’s adjuvant (CFA)-induced mouse model. APN wild type (WT) and knockout (KO) mouse were employed in the study. We found that EA attenuates the CFA-induced pain as demonstrated by the Hargreaves thermal test and the von Frey filament test. The deletion of APN significantly reduced the acupuncture analgesia in the CFA-treated APN KO mice while the intrathecal administration of APN mimicked the analgesic effects of EA. We further revealed that EA produced analgesic effects mainly via APN/AdipoR2-mediated AMPK pathway by the siRNA inhibitions of APN receptors (adipoR1/2) in the spinal cord. The immunofluorescence staining analysis showed that EA increased the APN accumulation in spinal cord through the blood circulation. In conclusion, the study indicates a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMPK pathway in the spinal cord.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi-
dc.relation.ispartofBrain, Behavior, and Immunity-
dc.subjectAdiponectin-
dc.subjectAdipoR-
dc.subjectAMPK-
dc.subjectelectroacupuncture-
dc.subjectacupuncture analgesia-
dc.titleAdiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord-
dc.typeArticle-
dc.identifier.emailNing, Z: milo5001@HKUCC-COM.hku.hk-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.emailLao, L: lxlao1@HKUCC-COM.hku.hk-
dc.identifier.emailChen, H: haiyong@hku.hk-
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hk-
dc.identifier.authorityCheung, CW=rp00244-
dc.identifier.authorityLao, L=rp01784-
dc.identifier.authorityChen, H=rp01923-
dc.identifier.authorityZhang, ZJ=rp01297-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbi.2021.09.010-
dc.identifier.pmid34562596-
dc.identifier.scopuseid_2-s2.0-85115925191-
dc.identifier.hkuros328473-
dc.identifier.volume99-
dc.identifier.spage43-
dc.identifier.epage52-
dc.identifier.isiWOS:000729654200007-
dc.publisher.placeUnited States-

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