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- Publisher Website: 10.1002/adma.202007379
- Scopus: eid_2-s2.0-85101569996
- PMID: 33629757
- WOS: WOS:000621458100001
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Article: Polymerization-Mediated Multifunctionalization of Living Cells for Enhanced Cell-Based Therapy
Title | Polymerization-Mediated Multifunctionalization of Living Cells for Enhanced Cell-Based Therapy |
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Authors | |
Keywords | cell-based therapy colitis multifunctionalization oral delivery surface decoration |
Issue Date | 2021 |
Publisher | Wiley-VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089 |
Citation | Advanced Materials, 2021, v. 33 n. 13, p. article no. 2007379 How to Cite? |
Abstract | Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays a critical role in cell-based therapy. Here, a facile yet versatile approach for decorating individual living cells with multimodal coatings is reported. By simply co-depositing with dopamine under a cytocompatible condition, various functional small molecules and polymers can be encoded to form a multifunctional coating on a cell's surface. The accessibility and versatility of this method to decorate diverse cells, including bacteria, fungi, and mammalian cells is demonstrated. With the ability to tune surface functions, ligand co-deposited gut microbiota is prepared as oral therapeutics for targeted treatment of colitis. Given the dual cytoprotective and targeting effects of the coating, decorated cells show more than 30-times higher bioavailability in the gut and fourfold higher accumulation in the inflamed tissue in comparison with those of uncoated bacteria. Multimodal therapeutic cells further validate strikingly increased treatment efficacy over clinical aminosalicylic acid in colitis mice. Decorating with multifunctional coatings proposes a robust platform for developing multimodal cells for enhanced cell-based therapy. |
Persistent Identifier | http://hdl.handle.net/10722/306349 |
ISSN | 2023 Impact Factor: 27.4 2023 SCImago Journal Rankings: 9.191 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pan, C | - |
dc.contributor.author | Li, J | - |
dc.contributor.author | Hou, W | - |
dc.contributor.author | Lin, S | - |
dc.contributor.author | Wang, L | - |
dc.contributor.author | Pang, Y | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Liu, J | - |
dc.date.accessioned | 2021-10-20T10:22:22Z | - |
dc.date.available | 2021-10-20T10:22:22Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Advanced Materials, 2021, v. 33 n. 13, p. article no. 2007379 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | http://hdl.handle.net/10722/306349 | - |
dc.description.abstract | Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays a critical role in cell-based therapy. Here, a facile yet versatile approach for decorating individual living cells with multimodal coatings is reported. By simply co-depositing with dopamine under a cytocompatible condition, various functional small molecules and polymers can be encoded to form a multifunctional coating on a cell's surface. The accessibility and versatility of this method to decorate diverse cells, including bacteria, fungi, and mammalian cells is demonstrated. With the ability to tune surface functions, ligand co-deposited gut microbiota is prepared as oral therapeutics for targeted treatment of colitis. Given the dual cytoprotective and targeting effects of the coating, decorated cells show more than 30-times higher bioavailability in the gut and fourfold higher accumulation in the inflamed tissue in comparison with those of uncoated bacteria. Multimodal therapeutic cells further validate strikingly increased treatment efficacy over clinical aminosalicylic acid in colitis mice. Decorating with multifunctional coatings proposes a robust platform for developing multimodal cells for enhanced cell-based therapy. | - |
dc.language | eng | - |
dc.publisher | Wiley-VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089 | - |
dc.relation.ispartof | Advanced Materials | - |
dc.rights | Submitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | cell-based therapy | - |
dc.subject | colitis | - |
dc.subject | multifunctionalization | - |
dc.subject | oral delivery | - |
dc.subject | surface decoration | - |
dc.title | Polymerization-Mediated Multifunctionalization of Living Cells for Enhanced Cell-Based Therapy | - |
dc.type | Article | - |
dc.identifier.email | Wang, Y: wanglab@hku.hk | - |
dc.identifier.authority | Wang, Y=rp02191 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adma.202007379 | - |
dc.identifier.pmid | 33629757 | - |
dc.identifier.scopus | eid_2-s2.0-85101569996 | - |
dc.identifier.hkuros | 327602 | - |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | article no. 2007379 | - |
dc.identifier.epage | article no. 2007379 | - |
dc.identifier.isi | WOS:000621458100001 | - |
dc.publisher.place | Germany | - |