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Article: New antimicrobial and collagen crosslinking formulated dentin adhesive with improved bond durability

TitleNew antimicrobial and collagen crosslinking formulated dentin adhesive with improved bond durability
Authors
KeywordsDentin bonding
Collagen crosslinking
Quaternary ammonium
Riboflavin
Antibacterial
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/17516161
Citation
Journal of the Mechanical Behavior of Biomedical Materials, 2020, v. 110, p. article no. 103927 How to Cite?
AbstractObjective: Here we describe a novel formulation, based on quaternary ammonium (QA) and riboflavin (RF), which combines antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities, was investigated. Methods: Experimental adhesives modified with different fractions of dioctadecyldimethyl ammonium bromide quaternary ammonium and riboflavin (QARF) were formulated. Dentine specimens were bonded to resincomposites with control or the experimental adhesives to be evaluated for bond strength, interfacial morphology, micro-Raman analysis, nano-CT and nano-leakage expression. In addition, the antibacterial and biocompatibilities of the experimental adhesives were investigated. The endogenous proteases activities and their molecular binding-sites were studied. Results: Modifying the experimental adhesives with QARF did not adversely affect micro-tensile bond strength or the degree of conversion along with the demonstration of anti-proteases and antibacterial abilities with acceptable biocompatibilities. In general, all experimental adhesives demonstrated favourable bond strength with increased and improved values in 1% QARF adhesive at 24 h (39.2 ± 3.0 MPa) and following thermocycling (34.8 ± 4.3 MPa). Significance: It is possible to conclude that the use of QARF with defined concentration can maintain bond strength values when an appropriate protocol is used and have contributed in ensuring a significant decrease in microbial growth of biofilms. Incorporation of 1% QARF in the experimental adhesive lead to simultaneous antimicrobial and anti-proteolytic effects with low cytotoxic effects, acceptable bond strength and interfacial morphology.
Persistent Identifierhttp://hdl.handle.net/10722/306330
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.748
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDaood, U-
dc.contributor.authorOmar, H-
dc.contributor.authorQasim, S-
dc.contributor.authorNogueira, LP-
dc.contributor.authorPichika, MR-
dc.contributor.authorMak, KK-
dc.contributor.authorSteier, L-
dc.contributor.authorYiu, CKY-
dc.contributor.authorLin, SL-
dc.contributor.authorFawzy, AS-
dc.date.accessioned2021-10-20T10:22:05Z-
dc.date.available2021-10-20T10:22:05Z-
dc.date.issued2020-
dc.identifier.citationJournal of the Mechanical Behavior of Biomedical Materials, 2020, v. 110, p. article no. 103927-
dc.identifier.issn1751-6161-
dc.identifier.urihttp://hdl.handle.net/10722/306330-
dc.description.abstractObjective: Here we describe a novel formulation, based on quaternary ammonium (QA) and riboflavin (RF), which combines antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities, was investigated. Methods: Experimental adhesives modified with different fractions of dioctadecyldimethyl ammonium bromide quaternary ammonium and riboflavin (QARF) were formulated. Dentine specimens were bonded to resincomposites with control or the experimental adhesives to be evaluated for bond strength, interfacial morphology, micro-Raman analysis, nano-CT and nano-leakage expression. In addition, the antibacterial and biocompatibilities of the experimental adhesives were investigated. The endogenous proteases activities and their molecular binding-sites were studied. Results: Modifying the experimental adhesives with QARF did not adversely affect micro-tensile bond strength or the degree of conversion along with the demonstration of anti-proteases and antibacterial abilities with acceptable biocompatibilities. In general, all experimental adhesives demonstrated favourable bond strength with increased and improved values in 1% QARF adhesive at 24 h (39.2 ± 3.0 MPa) and following thermocycling (34.8 ± 4.3 MPa). Significance: It is possible to conclude that the use of QARF with defined concentration can maintain bond strength values when an appropriate protocol is used and have contributed in ensuring a significant decrease in microbial growth of biofilms. Incorporation of 1% QARF in the experimental adhesive lead to simultaneous antimicrobial and anti-proteolytic effects with low cytotoxic effects, acceptable bond strength and interfacial morphology.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/17516161-
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materials-
dc.subjectDentin bonding-
dc.subjectCollagen crosslinking-
dc.subjectQuaternary ammonium-
dc.subjectRiboflavin-
dc.subjectAntibacterial-
dc.titleNew antimicrobial and collagen crosslinking formulated dentin adhesive with improved bond durability-
dc.typeArticle-
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hk-
dc.identifier.authorityYiu, CKY=rp00018-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jmbbm.2020.103927-
dc.identifier.pmid32957222-
dc.identifier.scopuseid_2-s2.0-85087481954-
dc.identifier.hkuros328323-
dc.identifier.volume110-
dc.identifier.spagearticle no. 103927-
dc.identifier.epagearticle no. 103927-
dc.identifier.isiWOS:000569168000004-
dc.publisher.placeNetherlands-

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