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Article: Changes in Default Mode Network Connectivity in Resting-State fMRI in People with Mild Dementia Receiving Cognitive Stimulation Therapy

TitleChanges in Default Mode Network Connectivity in Resting-State fMRI in People with Mild Dementia Receiving Cognitive Stimulation Therapy
Authors
KeywordsDMN
Dementia
Cognitive Stimulation Therapy (CST)
Resting-state fMRI
Cognitive reserve
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/brainsci
Citation
Brain Sciences, 2021, v. 11 n. 9, article no. 1137 How to Cite?
AbstractGroup cognitive stimulation therapy (CST) is a 7-week activity-based non-pharmacological intervention for people with mild to moderate dementia. Despite consistent evidence of clinical efficacy, the cognitive and brain mechanisms of CST remain unclear. Theoretically, group CST as a person-centred approach may work through promoting social interaction and personhood, executive function, and language use, especially in people with higher brain/cognitive reserve. To explore these putative mechanisms, structural MRI and resting-state functional MRI data were collected from 16 people with mild dementia before and after receiving CST, and in 13 dementia controls who received treatment as usual (TAU). Voxel-based morphometry (VBM) and resting-state functional connectivity (rs-FC) analyses were performed. Compared with TAU, the CST group maintained the total brain volume/total intracranial volume (TBV/TICV) ratio. Increased rs-FC in the default mode network (DMN) in the posterior cingulate cortex and bilateral parietal cortices nodes was observed in the CST over TAU groups between pre- and post-intervention timepoints. We provided preliminary evidence that CST maintains/enhances brain reserve both structurally and functionally. Considering the role of DMN in episodic memory retrieval and mental self-representation, preservation of personhood may be an important mechanism of CST for further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/306168
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.796
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, T-
dc.contributor.authorSpector, A-
dc.contributor.authorMograbi, DC-
dc.contributor.authorCheung, G-
dc.contributor.authorWong, GHY-
dc.date.accessioned2021-10-20T10:19:45Z-
dc.date.available2021-10-20T10:19:45Z-
dc.date.issued2021-
dc.identifier.citationBrain Sciences, 2021, v. 11 n. 9, article no. 1137-
dc.identifier.issn2076-3425-
dc.identifier.urihttp://hdl.handle.net/10722/306168-
dc.description.abstractGroup cognitive stimulation therapy (CST) is a 7-week activity-based non-pharmacological intervention for people with mild to moderate dementia. Despite consistent evidence of clinical efficacy, the cognitive and brain mechanisms of CST remain unclear. Theoretically, group CST as a person-centred approach may work through promoting social interaction and personhood, executive function, and language use, especially in people with higher brain/cognitive reserve. To explore these putative mechanisms, structural MRI and resting-state functional MRI data were collected from 16 people with mild dementia before and after receiving CST, and in 13 dementia controls who received treatment as usual (TAU). Voxel-based morphometry (VBM) and resting-state functional connectivity (rs-FC) analyses were performed. Compared with TAU, the CST group maintained the total brain volume/total intracranial volume (TBV/TICV) ratio. Increased rs-FC in the default mode network (DMN) in the posterior cingulate cortex and bilateral parietal cortices nodes was observed in the CST over TAU groups between pre- and post-intervention timepoints. We provided preliminary evidence that CST maintains/enhances brain reserve both structurally and functionally. Considering the role of DMN in episodic memory retrieval and mental self-representation, preservation of personhood may be an important mechanism of CST for further investigation.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/brainsci-
dc.relation.ispartofBrain Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDMN-
dc.subjectDementia-
dc.subjectCognitive Stimulation Therapy (CST)-
dc.subjectResting-state fMRI-
dc.subjectCognitive reserve-
dc.titleChanges in Default Mode Network Connectivity in Resting-State fMRI in People with Mild Dementia Receiving Cognitive Stimulation Therapy-
dc.typeArticle-
dc.identifier.emailLiu, T: tianyin@hku.hk-
dc.identifier.emailWong, GHY: ghywong@hku.hk-
dc.identifier.authorityLiu, T=rp02466-
dc.identifier.authorityWong, GHY=rp01850-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/brainsci11091137-
dc.identifier.pmid34573159-
dc.identifier.pmcidPMC8468883-
dc.identifier.scopuseid_2-s2.0-85114644493-
dc.identifier.hkuros326953-
dc.identifier.volume11-
dc.identifier.issue9-
dc.identifier.spagearticle no. 1137-
dc.identifier.epagearticle no. 1137-
dc.identifier.isiWOS:000699734100001-
dc.publisher.placeSwitzerland-

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