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Article: Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles

TitleCurrent Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles
Authors
Keywordsprimordial follicles
PI3K/PTEN signaling
in vitro activation
oocyte
granulosa cells
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells
Citation
Cells, 2021, v. 10 n. 6, p. article no. 1491 How to Cite?
AbstractThe mammalian ovary has two main functions—producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and activation of primordial follicles is the first step in follicular development and is the key factor in determining the reproductive capacity of females. The recent identification of the phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway as the key controller for follicular activation has made the study of primordial follicle activation a hot research topic in the field of reproduction. This review systematically summarizes the roles of the PI3K/PTEN signaling pathway in primordial follicle activation and discusses how the pathway interacts with various other molecular networks to control follicular activation. Studies on the activation of primordial follicles have led to the development of methods for the in vitro activation of primordial follicles as a treatment for infertility in women with premature ovarian insufficiency or poor ovarian response, and these are also discussed along with some practical applications of our current knowledge of follicular activation.
Persistent Identifierhttp://hdl.handle.net/10722/305933
ISSN
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.547
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Y-
dc.contributor.authorFeng, H-
dc.contributor.authorZHANG, Y-
dc.contributor.authorZhang, JV-
dc.contributor.authorWang, X-
dc.contributor.authorLiu, D-
dc.contributor.authorWang, T-
dc.contributor.authorLi, RHW-
dc.contributor.authorNg, EHY-
dc.contributor.authorYeung, WSB-
dc.contributor.authorRodriguez-Wallberg, KA-
dc.contributor.authorLiu, K-
dc.date.accessioned2021-10-20T10:16:25Z-
dc.date.available2021-10-20T10:16:25Z-
dc.date.issued2021-
dc.identifier.citationCells, 2021, v. 10 n. 6, p. article no. 1491-
dc.identifier.issn2073-4409-
dc.identifier.urihttp://hdl.handle.net/10722/305933-
dc.description.abstractThe mammalian ovary has two main functions—producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and activation of primordial follicles is the first step in follicular development and is the key factor in determining the reproductive capacity of females. The recent identification of the phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway as the key controller for follicular activation has made the study of primordial follicle activation a hot research topic in the field of reproduction. This review systematically summarizes the roles of the PI3K/PTEN signaling pathway in primordial follicle activation and discusses how the pathway interacts with various other molecular networks to control follicular activation. Studies on the activation of primordial follicles have led to the development of methods for the in vitro activation of primordial follicles as a treatment for infertility in women with premature ovarian insufficiency or poor ovarian response, and these are also discussed along with some practical applications of our current knowledge of follicular activation.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells-
dc.relation.ispartofCells-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectprimordial follicles-
dc.subjectPI3K/PTEN signaling-
dc.subjectin vitro activation-
dc.subjectoocyte-
dc.subjectgranulosa cells-
dc.titleCurrent Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles-
dc.typeArticle-
dc.identifier.emailFeng, H: fhw1010@hku.hk-
dc.identifier.emailLiu, D: liudt@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailLiu, K: kliugc@hku.hk-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityLiu, K=rp02475-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cells10061491-
dc.identifier.pmid34199299-
dc.identifier.pmcidPMC8231864-
dc.identifier.scopuseid_2-s2.0-85110377502-
dc.identifier.hkuros326641-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spagearticle no. 1491-
dc.identifier.epagearticle no. 1491-
dc.identifier.isiWOS:000665387600001-
dc.publisher.placeSwitzerland-

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