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Article: Epidemiology and Trends of Infective Meningitis in Neonates and Infants Less than 3 Months Old in Hong Kong

TitleEpidemiology and Trends of Infective Meningitis in Neonates and Infants Less than 3 Months Old in Hong Kong
Authors
KeywordsAntimicrobial resistance
Bacteria
Infants
Meningitis
Neonates
Issue Date2021
PublisherElsevier, published in association with International Society for Infectious Diseases. The Journal's web site is located at http://www.elsevier.com/locate/ijid
Citation
International Journal of Infectious Diseases, 2021, v. 111, p. 288-294 How to Cite?
AbstractObjectives: Meningitis in neonates and young infants leads to significant morbidity and mortality worldwide. This study aimed to investigate pathogens, antibiotic resistance and secular change of incidence in Hong Kong. Methods: A retrospective search was performed on meningitis in neonates and infants aged <3 months in three Hong Kong public hospitals from 2004 to 2019. Medical charts were reviewed, with focus on the identification and antibiotic resistance of the pathogens. Results: A total of 200 cases of meningitis were identified (67% were bacterial). Group B Streptococcus (GBS) and Escherichia coli ( E. coli ) were the commonest bacterial pathogens. The annual rates of early-onset GBS meningitis decreased after the implementation of universal GBS screening and intrapartum antibiotic prophylaxis (IAP) in 2012, while that of late-onset GBS meningitis remained similar. A significant portion of E. coli isolates were resistant to ampicillin and/or gentamicin. Conclusion: GBS and E. coli were the most common bacteria for meningitis in this age group. The annual rate of bacterial meningitis in Hong Kong has declined in recent years, which has been attributed to the decline in early-onset GBS meningitis due to universal GBS screening and IAP. Antimicrobial-resistant bacterial strains that cause meningitis require further clinical and public health attention.
Persistent Identifierhttp://hdl.handle.net/10722/305872
ISSN
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 1.435
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, CH-
dc.contributor.authorRosa Duque, J-
dc.contributor.authorWong, JSC-
dc.contributor.authorChan, CMV-
dc.contributor.authorLam, CSI-
dc.contributor.authorFu, YM-
dc.contributor.authorCheong, KN-
dc.contributor.authorChua, GT-
dc.contributor.authorLee, PP-
dc.contributor.authorIp, P-
dc.contributor.authorHo, MHK-
dc.contributor.authorWong, ICK-
dc.contributor.authorChan, GCF-
dc.contributor.authorLeung, WH-
dc.contributor.authorLee, SL-
dc.contributor.authorLee, KP-
dc.contributor.authorShek, CC-
dc.contributor.authorWong, MSR-
dc.contributor.authorWong, MSC-
dc.contributor.authorLau, YL-
dc.contributor.authorKwan, MYW-
dc.date.accessioned2021-10-20T10:15:31Z-
dc.date.available2021-10-20T10:15:31Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Infectious Diseases, 2021, v. 111, p. 288-294-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/10722/305872-
dc.description.abstractObjectives: Meningitis in neonates and young infants leads to significant morbidity and mortality worldwide. This study aimed to investigate pathogens, antibiotic resistance and secular change of incidence in Hong Kong. Methods: A retrospective search was performed on meningitis in neonates and infants aged <3 months in three Hong Kong public hospitals from 2004 to 2019. Medical charts were reviewed, with focus on the identification and antibiotic resistance of the pathogens. Results: A total of 200 cases of meningitis were identified (67% were bacterial). Group B Streptococcus (GBS) and Escherichia coli ( E. coli ) were the commonest bacterial pathogens. The annual rates of early-onset GBS meningitis decreased after the implementation of universal GBS screening and intrapartum antibiotic prophylaxis (IAP) in 2012, while that of late-onset GBS meningitis remained similar. A significant portion of E. coli isolates were resistant to ampicillin and/or gentamicin. Conclusion: GBS and E. coli were the most common bacteria for meningitis in this age group. The annual rate of bacterial meningitis in Hong Kong has declined in recent years, which has been attributed to the decline in early-onset GBS meningitis due to universal GBS screening and IAP. Antimicrobial-resistant bacterial strains that cause meningitis require further clinical and public health attention.-
dc.languageeng-
dc.publisherElsevier, published in association with International Society for Infectious Diseases. The Journal's web site is located at http://www.elsevier.com/locate/ijid-
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntimicrobial resistance-
dc.subjectBacteria-
dc.subjectInfants-
dc.subjectMeningitis-
dc.subjectNeonates-
dc.titleEpidemiology and Trends of Infective Meningitis in Neonates and Infants Less than 3 Months Old in Hong Kong-
dc.typeArticle-
dc.identifier.emailRosa Duque, J: jsrduque@hku.hk-
dc.identifier.emailChan, CMV: chimanc@hku.hk-
dc.identifier.emailCheong, KN: kncheong@hku.hk-
dc.identifier.emailChua, GT: cgt560@hku.hk-
dc.identifier.emailLee, PP: ppwlee@hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailHo, MHK: marcoho@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailLeung, WH: leungwhf@hku.hk-
dc.identifier.emailLee, SL: slleem@hku.hk-
dc.identifier.emailLee, KP: lee1965@hkucc.hku.hk-
dc.identifier.emailShek, CC: shekcc@hku.hk-
dc.identifier.emailWong, MSR: wongmsr@hku.hk-
dc.identifier.emailWong, MSC: mscwong@hkucc.hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.emailKwan, MYW: ywmkwan@hku.hk-
dc.identifier.authorityRosa Duque, J=rp02340-
dc.identifier.authorityChua, GT=rp02684-
dc.identifier.authorityLee, PP=rp00462-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityLeung, WH=rp02760-
dc.identifier.authorityLau, YL=rp00361-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ijid.2021.06.025-
dc.identifier.pmid34217874-
dc.identifier.scopuseid_2-s2.0-85115167300-
dc.identifier.hkuros328064-
dc.identifier.volume111-
dc.identifier.spage288-
dc.identifier.epage294-
dc.identifier.isiWOS:000705862800006-
dc.publisher.placeUnited Kingdom-

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