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Article: Metformin Hydrochloride Encapsulation by Alginate Strontium Hydrogel for Cartilage Regeneration by Reliving Cellular Senescence

TitleMetformin Hydrochloride Encapsulation by Alginate Strontium Hydrogel for Cartilage Regeneration by Reliving Cellular Senescence
Authors
Issue Date2021
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/biomac
Citation
Biomacromolecules, 2021, v. 22 n. 2, p. 671-680 How to Cite?
AbstractCartilage lesion is a common tissue defect and is challenging in clinical practice. Trauma-induced cellular senescence could decrease the chondrocyte capability of maintaining cartilage tissue regeneration. A previous investigation showed that, by controlling the cellular senescence, the cartilage regeneration can be significantly accelerated. Based on this finding, we design a novel hydrogel, Alg/MH-Sr, that combines metformin, an established drug for inhibiting senescence, and strontium, an effective anti-inflammatory material for cartilage tissue engineering. A RT-PCR test suggests the significant inhibitory effect of the hydrogel on senescent, apoptotic, oxidative, and inflammatory genes’ expression. Histological examinations demonstrate that the Alg/MH-Sr hydrogel accelerated cartilage repairment, and chondrocyte senescence was significantly inhibited. Our study demonstrates that the Alg/MH-Sr hydrogel is effective for cartilage defect treatment and provides a new clue in accelerating tissue repairment by inhibiting the senescence of cells and tissues.
Persistent Identifierhttp://hdl.handle.net/10722/305863
ISSN
2023 Impact Factor: 5.5
2023 SCImago Journal Rankings: 1.232
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXU, L-
dc.contributor.authorMA, F-
dc.contributor.authorHUANG, J-
dc.contributor.authorLeung, KLF-
dc.contributor.authorQIN, C-
dc.contributor.authorLu, WW-
dc.contributor.authorGUO, XE-
dc.contributor.authorTANG, B-
dc.date.accessioned2021-10-20T10:15:24Z-
dc.date.available2021-10-20T10:15:24Z-
dc.date.issued2021-
dc.identifier.citationBiomacromolecules, 2021, v. 22 n. 2, p. 671-680-
dc.identifier.issn1525-7797-
dc.identifier.urihttp://hdl.handle.net/10722/305863-
dc.description.abstractCartilage lesion is a common tissue defect and is challenging in clinical practice. Trauma-induced cellular senescence could decrease the chondrocyte capability of maintaining cartilage tissue regeneration. A previous investigation showed that, by controlling the cellular senescence, the cartilage regeneration can be significantly accelerated. Based on this finding, we design a novel hydrogel, Alg/MH-Sr, that combines metformin, an established drug for inhibiting senescence, and strontium, an effective anti-inflammatory material for cartilage tissue engineering. A RT-PCR test suggests the significant inhibitory effect of the hydrogel on senescent, apoptotic, oxidative, and inflammatory genes’ expression. Histological examinations demonstrate that the Alg/MH-Sr hydrogel accelerated cartilage repairment, and chondrocyte senescence was significantly inhibited. Our study demonstrates that the Alg/MH-Sr hydrogel is effective for cartilage defect treatment and provides a new clue in accelerating tissue repairment by inhibiting the senescence of cells and tissues.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/biomac-
dc.relation.ispartofBiomacromolecules-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.titleMetformin Hydrochloride Encapsulation by Alginate Strontium Hydrogel for Cartilage Regeneration by Reliving Cellular Senescence-
dc.typeArticle-
dc.identifier.emailLeung, KLF: klleunga@hkucc.hku.hk-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.authorityLeung, KLF=rp00297-
dc.identifier.authorityLu, WW=rp00411-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.biomac.0c01488-
dc.identifier.scopuseid_2-s2.0-85100270478-
dc.identifier.hkuros327523-
dc.identifier.volume22-
dc.identifier.issue2-
dc.identifier.spage671-
dc.identifier.epage680-
dc.identifier.isiWOS:000618660700038-
dc.publisher.placeUnited States-

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