File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Efficacy and acceptability of transcranial direct current stimulation for treating depression: A meta-analysis of randomized controlled trials

TitleEfficacy and acceptability of transcranial direct current stimulation for treating depression: A meta-analysis of randomized controlled trials
Authors
KeywordstDCS
Depression
Meta-analysis
Clinical response
Remission
Issue Date2021
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev
Citation
Neuroscience & Biobehavioral Reviews, 2021, v. 126, p. 481-490 How to Cite?
AbstractBackground: Transcranial direct current stimulation (tDCS) is a promising nonpharmacological intervention for treating depression. We aimed to provide an updated meta-analysis assessing the anti-depressant efficacy of tDCS. Methods: We searched the literature from the first available date to 30 December 2020 to identify relevant randomized controlled trials (RCTs). Results: 27 RCTs (N = 1204 patients, 653 in active tDCS and 551 in sham tDCS) were included. Active tDCS was superior to sham tDCS (g = 0.46, 95 % CI 0.15−0.76) in modulating depressive symptoms measured by depression rating scales. Active tDCS was also superior to sham tDCS in reducing response and remission rates, but these differences did not reach statistically significant levels (ORresponse = 1.75, 95 % CI 0.85–3.58; ORremission = 1.29, 95 % CI 0.59–2.83). The two groups had comparable dropout rates (OR = 1.28, 95 % CI 0.62–1.64). Conclusion: For treatments of depressive episodes, tDCS may be efficacious. Specific tDCS parameters (e.g., a 2-mA stimulation current and 30-min sessions) and clinical characteristics (e.g., antidepressant-free) may augment the treatment efficacy of tDCS.
Persistent Identifierhttp://hdl.handle.net/10722/305756
ISSN
2020 Impact Factor: 8.989
2020 SCImago Journal Rankings: 3.590
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, R-
dc.contributor.authorLam, CLM-
dc.contributor.authorPeng, X-
dc.contributor.authorZhang, D-
dc.contributor.authorZhang, C-
dc.contributor.authorHuang, R-
dc.contributor.authorLee, TMC-
dc.date.accessioned2021-10-20T10:13:53Z-
dc.date.available2021-10-20T10:13:53Z-
dc.date.issued2021-
dc.identifier.citationNeuroscience & Biobehavioral Reviews, 2021, v. 126, p. 481-490-
dc.identifier.issn0149-7634-
dc.identifier.urihttp://hdl.handle.net/10722/305756-
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS) is a promising nonpharmacological intervention for treating depression. We aimed to provide an updated meta-analysis assessing the anti-depressant efficacy of tDCS. Methods: We searched the literature from the first available date to 30 December 2020 to identify relevant randomized controlled trials (RCTs). Results: 27 RCTs (N = 1204 patients, 653 in active tDCS and 551 in sham tDCS) were included. Active tDCS was superior to sham tDCS (g = 0.46, 95 % CI 0.15−0.76) in modulating depressive symptoms measured by depression rating scales. Active tDCS was also superior to sham tDCS in reducing response and remission rates, but these differences did not reach statistically significant levels (ORresponse = 1.75, 95 % CI 0.85–3.58; ORremission = 1.29, 95 % CI 0.59–2.83). The two groups had comparable dropout rates (OR = 1.28, 95 % CI 0.62–1.64). Conclusion: For treatments of depressive episodes, tDCS may be efficacious. Specific tDCS parameters (e.g., a 2-mA stimulation current and 30-min sessions) and clinical characteristics (e.g., antidepressant-free) may augment the treatment efficacy of tDCS.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev-
dc.relation.ispartofNeuroscience & Biobehavioral Reviews-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjecttDCS-
dc.subjectDepression-
dc.subjectMeta-analysis-
dc.subjectClinical response-
dc.subjectRemission-
dc.titleEfficacy and acceptability of transcranial direct current stimulation for treating depression: A meta-analysis of randomized controlled trials-
dc.typeArticle-
dc.identifier.emailLam, CLM: charlene.lam@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityLam, CLM=rp02784-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neubiorev.2021.03.026-
dc.identifier.pmid33789158-
dc.identifier.scopuseid_2-s2.0-85104124234-
dc.identifier.hkuros328018-
dc.identifier.volume126-
dc.identifier.spage481-
dc.identifier.epage490-
dc.identifier.isiWOS:000656710800005-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats