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- Publisher Website: 10.1038/s41598-021-93360-z
- Scopus: eid_2-s2.0-85109399730
- PMID: 34234209
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Article: Investigating the association of testosterone with survival in men and women using a Mendelian randomization study in the UK Biobank
Title | Investigating the association of testosterone with survival in men and women using a Mendelian randomization study in the UK Biobank |
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Authors | |
Issue Date | 2021 |
Publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2021, v. 11, p. article no. 14039 How to Cite? |
Abstract | Life expectancy in the developed West is currently stagnated and remains shorter in men than women. Well-established evolutionary biology theory suggests lifespan trades-off against reproductive success, possibly sex-specifically. We examined whether a key driver of reproductive success, testosterone, affected survival using a Mendelian randomization longevity study in the UK Biobank to obtain unbiased estimates, along with control exposures. We applied published genetic instruments for testosterone to obtain inverse variance weighted estimates of associations with survival to (i.e., age at) recruitment, in 167,020 men and 194,174 women. We similarly obtained estimates for a positive control (smoking initiation), and a negative control (absorbate), a marker of vitamin C metabolism. Testosterone was associated with poorer survival (0.10 years younger at recruitment per effect size of testosterone, 95% confidence interval (CI) 0.004 to 0.20). As expected, smoking initiation was also associated with poorer survival (0.37 years younger, 95% CI 0.25 to 0.50), but not absorbate (0.01 years younger, 95% CI − 0.09 to 0.11). Several aspects of a healthy lifestyle (low animal fat diet) and several widely used medications (statins, metformin, dexamethasone and possibly aspirin) may modulate testosterone. Explicitly designing interventions sex-specifically based on these insights might help address stagnating life expectancy and sexual disparities. |
Persistent Identifier | http://hdl.handle.net/10722/305703 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schooling, CM | - |
dc.contributor.author | Zhao, JV | - |
dc.date.accessioned | 2021-10-20T10:13:07Z | - |
dc.date.available | 2021-10-20T10:13:07Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Scientific Reports, 2021, v. 11, p. article no. 14039 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305703 | - |
dc.description.abstract | Life expectancy in the developed West is currently stagnated and remains shorter in men than women. Well-established evolutionary biology theory suggests lifespan trades-off against reproductive success, possibly sex-specifically. We examined whether a key driver of reproductive success, testosterone, affected survival using a Mendelian randomization longevity study in the UK Biobank to obtain unbiased estimates, along with control exposures. We applied published genetic instruments for testosterone to obtain inverse variance weighted estimates of associations with survival to (i.e., age at) recruitment, in 167,020 men and 194,174 women. We similarly obtained estimates for a positive control (smoking initiation), and a negative control (absorbate), a marker of vitamin C metabolism. Testosterone was associated with poorer survival (0.10 years younger at recruitment per effect size of testosterone, 95% confidence interval (CI) 0.004 to 0.20). As expected, smoking initiation was also associated with poorer survival (0.37 years younger, 95% CI 0.25 to 0.50), but not absorbate (0.01 years younger, 95% CI − 0.09 to 0.11). Several aspects of a healthy lifestyle (low animal fat diet) and several widely used medications (statins, metformin, dexamethasone and possibly aspirin) may modulate testosterone. Explicitly designing interventions sex-specifically based on these insights might help address stagnating life expectancy and sexual disparities. | - |
dc.language | eng | - |
dc.publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | Scientific Reports. Copyright © Nature Research: Fully open access journals. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Investigating the association of testosterone with survival in men and women using a Mendelian randomization study in the UK Biobank | - |
dc.type | Article | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.email | Zhao, JV: janezhao@hku.hk | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.identifier.authority | Zhao, JV=rp02336 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-021-93360-z | - |
dc.identifier.pmid | 34234209 | - |
dc.identifier.pmcid | PMC8263740 | - |
dc.identifier.scopus | eid_2-s2.0-85109399730 | - |
dc.identifier.hkuros | 328035 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 14039 | - |
dc.identifier.epage | article no. 14039 | - |
dc.identifier.isi | WOS:000674553000002 | - |
dc.publisher.place | United Kingdom | - |