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Article: Genomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations

TitleGenomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations
Authors
KeywordsGenomics
Adaptation
Molecular evolution
Cold adaptation
Relaxation
Issue Date2020
PublisherOxford University Press, published in association with Society for Molecular Biology and Evolution. The Journal's web site is located at http://mbe.oxfordjournals.org/
Citation
Molecular Biology and Evolution, 2020, v. 37 n. 8, p. 2211-2227 How to Cite?
AbstractUnderstanding how organisms adapt to extreme environments is fundamental and can provide insightful case studies for both evolutionary biology and climate-change biology. Here, we take advantage of the vast diversity of lifestyles in ants to identify genomic signatures of adaptation to extreme habitats such as high altitude. We hypothesized two parallel patterns would occur in a genome adapting to an extreme habitat: 1) strong positive selection on genes related to adaptation and 2) a relaxation of previous purifying selection. We tested this hypothesis by sequencing the high-elevation specialist Tetramorium alpestre and four other phylogenetically related species. In support of our hypothesis, we recorded a strong shift of selective forces in T. alpestre, in particular a stronger magnitude of diversifying and relaxed selection when compared with all other ants. We further disentangled candidate molecular adaptations in both gene expression and protein-coding sequence that were identified by our genome-wide analyses. In particular, we demonstrate that T. alpestre has 1) a higher level of expression for stv and other heat-shock proteins in chill-shock tests and 2) enzymatic enhancement of Hex-T1, a rate-limiting regulatory enzyme that controls the entry of glucose into the glycolytic pathway. Together, our analyses highlight the adaptive molecular changes that support colonization of high-altitude environments.
Persistent Identifierhttp://hdl.handle.net/10722/305603
ISSN
2023 Impact Factor: 11.0
2023 SCImago Journal Rankings: 4.061
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCicconardi, F-
dc.contributor.authorKrapf, P-
dc.contributor.authorD’Annessa, I-
dc.contributor.authorGamisch, A-
dc.contributor.authorWagner, HC-
dc.contributor.authorNguyen, AD-
dc.contributor.authorEconomo, EP-
dc.contributor.authorMikheyev, AS-
dc.contributor.authorGuénard, B-
dc.contributor.authorGrabherr, R-
dc.contributor.authorAndesner, P-
dc.contributor.authorWolfgang, A-
dc.contributor.authorDi Marino, D-
dc.contributor.authorSteiner, FM-
dc.contributor.authorSchlick-Steiner, BC-
dc.date.accessioned2021-10-20T10:11:44Z-
dc.date.available2021-10-20T10:11:44Z-
dc.date.issued2020-
dc.identifier.citationMolecular Biology and Evolution, 2020, v. 37 n. 8, p. 2211-2227-
dc.identifier.issn0737-4038-
dc.identifier.urihttp://hdl.handle.net/10722/305603-
dc.description.abstractUnderstanding how organisms adapt to extreme environments is fundamental and can provide insightful case studies for both evolutionary biology and climate-change biology. Here, we take advantage of the vast diversity of lifestyles in ants to identify genomic signatures of adaptation to extreme habitats such as high altitude. We hypothesized two parallel patterns would occur in a genome adapting to an extreme habitat: 1) strong positive selection on genes related to adaptation and 2) a relaxation of previous purifying selection. We tested this hypothesis by sequencing the high-elevation specialist Tetramorium alpestre and four other phylogenetically related species. In support of our hypothesis, we recorded a strong shift of selective forces in T. alpestre, in particular a stronger magnitude of diversifying and relaxed selection when compared with all other ants. We further disentangled candidate molecular adaptations in both gene expression and protein-coding sequence that were identified by our genome-wide analyses. In particular, we demonstrate that T. alpestre has 1) a higher level of expression for stv and other heat-shock proteins in chill-shock tests and 2) enzymatic enhancement of Hex-T1, a rate-limiting regulatory enzyme that controls the entry of glucose into the glycolytic pathway. Together, our analyses highlight the adaptive molecular changes that support colonization of high-altitude environments.-
dc.languageeng-
dc.publisherOxford University Press, published in association with Society for Molecular Biology and Evolution. The Journal's web site is located at http://mbe.oxfordjournals.org/-
dc.relation.ispartofMolecular Biology and Evolution-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectGenomics-
dc.subjectAdaptation-
dc.subjectMolecular evolution-
dc.subjectCold adaptation-
dc.subjectRelaxation-
dc.titleGenomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations-
dc.typeArticle-
dc.identifier.emailGuénard, B: bguenard@hku.hk-
dc.identifier.authorityGuénard, B=rp01963-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/molbev/msaa076-
dc.identifier.pmid32181804-
dc.identifier.pmcidPMC7403626-
dc.identifier.scopuseid_2-s2.0-85089203538-
dc.identifier.hkuros328256-
dc.identifier.volume37-
dc.identifier.issue8-
dc.identifier.spage2211-
dc.identifier.epage2227-
dc.identifier.isiWOS:000574381000005-
dc.publisher.placeUnited States-

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