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Article: Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

TitleClay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair
Authors
Issue Date2021
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/tb#!recentarticles&all
Citation
Journal of Materials Chemistry B, 2021, v. 9 n. 10, p. 2394-2406 How to Cite?
AbstractAlthough clay-based nanocomposite hydrogels have been widely explored, their instability in hot water and saline solution inhibits their applications in biomedical engineering, and the exploration of clay-based nanocomposite hydrogels in bone defect repair is even less. In this work, we developed a stable clay-based nanocomposite hydrogel using 4-acryloylmorpholine as the monomer. After UV light illumination, the obtained poly(4-acryloylmorpholine) clay-based nanocomposite hydrogel (poly(4-acry)–clay nanocomposite hydrogel) exhibits excellent mechanical properties due to the hydrogen bond interactions between the poly(4-acryloylmorpholine) chains and the physical crosslinking effect of the nanoclay. Besides good biocompatibility, the sustainable release of intrinsic Mg2+ and Si4+ from the poly(4-acry)–clay nanocomposite hydrogel endows the system with excellent ability to promote the osteogenic differentiation of primary rat osteoblasts (ROBs) and can promote new bone formation effectively after implantation. We anticipate that these kinds of clay-based nanocomposite hydrogels with sustained release of bioactive ions will open a new avenue for the development of novel biomaterials for bone regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/305409
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.216
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZHAI, X-
dc.contributor.authorRUAN, C-
dc.contributor.authorSHEN, J-
dc.contributor.authorZHENG, C-
dc.contributor.authorZHAO, X-
dc.contributor.authorPAN, H-
dc.contributor.authorLu, WW-
dc.date.accessioned2021-10-20T10:09:00Z-
dc.date.available2021-10-20T10:09:00Z-
dc.date.issued2021-
dc.identifier.citationJournal of Materials Chemistry B, 2021, v. 9 n. 10, p. 2394-2406-
dc.identifier.issn2050-750X-
dc.identifier.urihttp://hdl.handle.net/10722/305409-
dc.description.abstractAlthough clay-based nanocomposite hydrogels have been widely explored, their instability in hot water and saline solution inhibits their applications in biomedical engineering, and the exploration of clay-based nanocomposite hydrogels in bone defect repair is even less. In this work, we developed a stable clay-based nanocomposite hydrogel using 4-acryloylmorpholine as the monomer. After UV light illumination, the obtained poly(4-acryloylmorpholine) clay-based nanocomposite hydrogel (poly(4-acry)–clay nanocomposite hydrogel) exhibits excellent mechanical properties due to the hydrogen bond interactions between the poly(4-acryloylmorpholine) chains and the physical crosslinking effect of the nanoclay. Besides good biocompatibility, the sustainable release of intrinsic Mg2+ and Si4+ from the poly(4-acry)–clay nanocomposite hydrogel endows the system with excellent ability to promote the osteogenic differentiation of primary rat osteoblasts (ROBs) and can promote new bone formation effectively after implantation. We anticipate that these kinds of clay-based nanocomposite hydrogels with sustained release of bioactive ions will open a new avenue for the development of novel biomaterials for bone regeneration.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/tb#!recentarticles&all-
dc.relation.ispartofJournal of Materials Chemistry B-
dc.titleClay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair-
dc.typeArticle-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.authorityLu, WW=rp00411-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/D1TB00184A-
dc.identifier.pmid33625433-
dc.identifier.scopuseid_2-s2.0-85102726978-
dc.identifier.hkuros327925-
dc.identifier.volume9-
dc.identifier.issue10-
dc.identifier.spage2394-
dc.identifier.epage2406-
dc.identifier.isiWOS:000629733200004-
dc.publisher.placeUnited Kingdom-

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