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- Publisher Website: 10.1038/s41413-020-00125-x
- Scopus: eid_2-s2.0-85100092178
- PMID: 33514693
- WOS: WOS:000613473200001
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Article: Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions
Title | Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions |
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Authors | |
Issue Date | 2021 |
Publisher | Springer Nature, published in partnership with Sichuan University. The Journal's web site is located at ttp://www.nature.com/boneres/ |
Citation | Bone Research, 2021, v. 9, article no. 7 How to Cite? |
Abstract | Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration, a significant contributor to LBP. Inflammatory mediators also play an indispensable role in discogenic LBP. The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies. Here, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction. Puncture models, mechanical models, and spontaneous models as the main animal models to study painful disc degeneration are discussed, and the underlying signaling pathways are summarized. Furthermore, potential drug candidates, either under laboratory investigation or undergoing clinical trials, to suppress discogenic LBP by eliminating inflammation are explored. We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research. |
Persistent Identifier | http://hdl.handle.net/10722/305401 |
ISSN | 2023 Impact Factor: 14.3 2023 SCImago Journal Rankings: 3.378 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lyu, F | - |
dc.contributor.author | Cui, H | - |
dc.contributor.author | Pan, H | - |
dc.contributor.author | Cheung, KMC | - |
dc.contributor.author | Cao, X | - |
dc.contributor.author | Iatridis, JC | - |
dc.contributor.author | Zheng, Z | - |
dc.date.accessioned | 2021-10-20T10:08:53Z | - |
dc.date.available | 2021-10-20T10:08:53Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Bone Research, 2021, v. 9, article no. 7 | - |
dc.identifier.issn | 2095-4700 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305401 | - |
dc.description.abstract | Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration, a significant contributor to LBP. Inflammatory mediators also play an indispensable role in discogenic LBP. The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies. Here, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction. Puncture models, mechanical models, and spontaneous models as the main animal models to study painful disc degeneration are discussed, and the underlying signaling pathways are summarized. Furthermore, potential drug candidates, either under laboratory investigation or undergoing clinical trials, to suppress discogenic LBP by eliminating inflammation are explored. We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research. | - |
dc.language | eng | - |
dc.publisher | Springer Nature, published in partnership with Sichuan University. The Journal's web site is located at ttp://www.nature.com/boneres/ | - |
dc.relation.ispartof | Bone Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions | - |
dc.type | Article | - |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41413-020-00125-x | - |
dc.identifier.pmid | 33514693 | - |
dc.identifier.pmcid | PMC7846842 | - |
dc.identifier.scopus | eid_2-s2.0-85100092178 | - |
dc.identifier.hkuros | 327446 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | article no. 7 | - |
dc.identifier.epage | article no. 7 | - |
dc.identifier.isi | WOS:000613473200001 | - |
dc.publisher.place | China | - |