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Article: Biofilm inhibition in oral pathogens by nanodiamonds

TitleBiofilm inhibition in oral pathogens by nanodiamonds
Authors
Issue Date2021
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all
Citation
Biomaterials Science, 2021, v. 9 n. 15, p. 5127-5135 How to Cite?
AbstractComplex microbial communities, e.g., biofilms residing in our oral cavity, have recognized clinical significance, as they are typically the main cause for infections. Particularly, they show high resistance to conventional antibiotics, and alternatives including nanotechnology are being intensively explored nowadays to provide more efficient therapeutics. Diamond nanoparticles, namely, nanodiamonds (NDs) with many promising physico-chemical properties, have been demonstrated to work as an effective antibacterial agent against planktonic cells (free-floating state). However, little is known about the behaviors of NDs against biofilms (sessile state). In this study, we uncovered their role in inhibiting biofilm formation and their disrupting effect on preformed biofilms in several selected orally and systemically important organisms. The current findings will advance the mechanistic understanding of NDs on oral pathogens and might accelerate corresponding clinical translation.
Persistent Identifierhttp://hdl.handle.net/10722/305351
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 1.206
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, T-
dc.contributor.authorKalimuthu, S-
dc.contributor.authorRajasekar, V-
dc.contributor.authorXu, F-
dc.contributor.authorYiu, YC-
dc.contributor.authorHui, TKC-
dc.contributor.authorNeelakantan, P-
dc.contributor.authorChu, Z-
dc.date.accessioned2021-10-20T10:08:11Z-
dc.date.available2021-10-20T10:08:11Z-
dc.date.issued2021-
dc.identifier.citationBiomaterials Science, 2021, v. 9 n. 15, p. 5127-5135-
dc.identifier.issn2047-4830-
dc.identifier.urihttp://hdl.handle.net/10722/305351-
dc.description.abstractComplex microbial communities, e.g., biofilms residing in our oral cavity, have recognized clinical significance, as they are typically the main cause for infections. Particularly, they show high resistance to conventional antibiotics, and alternatives including nanotechnology are being intensively explored nowadays to provide more efficient therapeutics. Diamond nanoparticles, namely, nanodiamonds (NDs) with many promising physico-chemical properties, have been demonstrated to work as an effective antibacterial agent against planktonic cells (free-floating state). However, little is known about the behaviors of NDs against biofilms (sessile state). In this study, we uncovered their role in inhibiting biofilm formation and their disrupting effect on preformed biofilms in several selected orally and systemically important organisms. The current findings will advance the mechanistic understanding of NDs on oral pathogens and might accelerate corresponding clinical translation.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all-
dc.relation.ispartofBiomaterials Science-
dc.titleBiofilm inhibition in oral pathogens by nanodiamonds-
dc.typeArticle-
dc.identifier.emailChu, Z: zqchu@eee.hku.hk-
dc.identifier.authorityChu, Z=rp02472-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/D1BM00608H-
dc.identifier.pmid33997876-
dc.identifier.scopuseid_2-s2.0-85109078922-
dc.identifier.hkuros328150-
dc.identifier.volume9-
dc.identifier.issue15-
dc.identifier.spage5127-
dc.identifier.epage5135-
dc.identifier.isiWOS:000651074900001-
dc.publisher.placeUnited Kingdom-

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