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Article: Cancer‐on‐a‐Chip for Modeling Immune Checkpoint Inhibitor and Tumor Interactions

TitleCancer‐on‐a‐Chip for Modeling Immune Checkpoint Inhibitor and Tumor Interactions
Authors
Keywordscancer immunotherapy
cancer-on-a-chip
drug screening
high-throughput observation chamber
immune checkpoint inhibitors
Issue Date2021
PublisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html
Citation
Small, 2021, v. 17 n. 7, p. article no. 2004282 How to Cite?
AbstractCancer immunotherapies, including immune checkpoint inhibitor (ICI)-based therapies, have revolutionized cancer treatment. However, patient response to ICIs is highly variable, necessitating the development of methods to quickly assess efficacy. In this study, an array of miniaturized bioreactors has been developed to model tumor-immune interactions. This immunotherapeutic high-throughput observation chamber (iHOC) is designed to test the effect of anti-PD-1 antibodies on cancer spheroid (MDA-MB-231, PD-L1+) and T cell (Jurkat) interactions. This system facilitates facile monitoring of T cell inhibition and reactivation using metrics such as tumor infiltration and interleukin-2 (IL-2) secretion. Status of the tumor-immune interactions can be easily captured within the iHOC by measuring IL-2 concentration using a micropillar array where sensitive, quantitative detection is allowed after antibody coating on the surface of array. The iHOC is a platform that can be used to model and monitor cancer-immune interactions in response to immunotherapy in a high-throughput manner.
Persistent Identifierhttp://hdl.handle.net/10722/305350
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, X-
dc.contributor.authorRen, L-
dc.contributor.authorTebon, P-
dc.contributor.authorWang, C-
dc.contributor.authorZhou, X-
dc.contributor.authorQu, M-
dc.contributor.authorZhu, J-
dc.contributor.authorLing, H-
dc.contributor.authorZhang, S-
dc.contributor.authorXue, Y-
dc.contributor.authorWu, Q-
dc.contributor.authorBandaru, P-
dc.contributor.authorLee, J-
dc.contributor.authorKim, H-
dc.contributor.authorAhadian, S-
dc.contributor.authorAshammakhi, N-
dc.contributor.authorDokmeci, M-
dc.contributor.authorWu, J-
dc.contributor.authorGu, Z-
dc.contributor.authorSun, W-
dc.contributor.authorKhademhosseini, A-
dc.date.accessioned2021-10-20T10:08:10Z-
dc.date.available2021-10-20T10:08:10Z-
dc.date.issued2021-
dc.identifier.citationSmall, 2021, v. 17 n. 7, p. article no. 2004282-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/305350-
dc.description.abstractCancer immunotherapies, including immune checkpoint inhibitor (ICI)-based therapies, have revolutionized cancer treatment. However, patient response to ICIs is highly variable, necessitating the development of methods to quickly assess efficacy. In this study, an array of miniaturized bioreactors has been developed to model tumor-immune interactions. This immunotherapeutic high-throughput observation chamber (iHOC) is designed to test the effect of anti-PD-1 antibodies on cancer spheroid (MDA-MB-231, PD-L1+) and T cell (Jurkat) interactions. This system facilitates facile monitoring of T cell inhibition and reactivation using metrics such as tumor infiltration and interleukin-2 (IL-2) secretion. Status of the tumor-immune interactions can be easily captured within the iHOC by measuring IL-2 concentration using a micropillar array where sensitive, quantitative detection is allowed after antibody coating on the surface of array. The iHOC is a platform that can be used to model and monitor cancer-immune interactions in response to immunotherapy in a high-throughput manner.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html-
dc.relation.ispartofSmall-
dc.rightsSmall. Copyright © Wiley - VCH Verlag GmbH & Co KGaA.-
dc.rightsSubmitted (preprint) Version: This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions Accepted (peer-reviewed) Version: This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.-
dc.subjectcancer immunotherapy-
dc.subjectcancer-on-a-chip-
dc.subjectdrug screening-
dc.subjecthigh-throughput observation chamber-
dc.subjectimmune checkpoint inhibitors-
dc.titleCancer‐on‐a‐Chip for Modeling Immune Checkpoint Inhibitor and Tumor Interactions-
dc.typeArticle-
dc.identifier.emailZhang, S: beszhang@hku.hk-
dc.identifier.authorityZhang, S=rp02764-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/smll.202004282-
dc.identifier.pmid33502118-
dc.identifier.pmcidPMC7939119-
dc.identifier.scopuseid_2-s2.0-85099812488-
dc.identifier.hkuros328139-
dc.identifier.volume17-
dc.identifier.issue7-
dc.identifier.spagearticle no. 2004282-
dc.identifier.epagearticle no. 2004282-
dc.identifier.isiWOS:000612164300001-
dc.publisher.placeGermany-

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