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Article: A multi-inversion-recovery magnetic resonance fingerprinting for multi-compartment water mapping

TitleA multi-inversion-recovery magnetic resonance fingerprinting for multi-compartment water mapping
Authors
KeywordsMyelin
Brain MRI
Multi-contrast MRI
MR fingerprinting
Issue Date2021
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
Citation
Magnetic Resonance Imaging, 2021, v. 81, p. 82-87 How to Cite?
AbstractPurpose: This study aimed at introducing short-T1/T2 compartment to MR fingerprinting (MRF) at 3 T. Water that is bound to myelin macromolecules have significantly shorter T1 and T2 than free water and can be distinguished from free water by multi-compartment analysis. Methods: We developed a new multi-inversion-recovery (mIR) water mapping-MRF based on an unbalanced steady-state coherent sequence (FISP). mIR pulses with an interval of 400 or 500 repetition times (TRs) were inserted into the conventional FISP MRF sequence. Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting. Three healthy volunteers were scanned with mIR MRF on a clinical 3 T MRI. Results: Using an extended phase graph simulation, we found that our proposed mIR scheme with four IR pulses allowed differentiation between short and long T1/T2 components. For in vivo experiments, we achieved the quantification of myelin water, gray matter water, and white matter water at an image resolution of 1.17 × 1.17 × 5 mm3/pixel. As compared to the conventional MRF technique with single IR, our proposed mIR improved the detection of myelin water content. In addition, mIR MRF using spiral-in/out trajectory provided a higher signal level compared with that with spiral-out trajectory. Myelin water quantification using mIR MRF with 4 IR and 5 IR pulses were qualitatively similar. Meanwhile, 5 IR MRF showed fewer artifacts in myelin water detection. Conclusion: We developed a new mIR MRF sequence for the rapid quantification of brain water compartments.
Persistent Identifierhttp://hdl.handle.net/10722/305312
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.647
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCui, D-
dc.contributor.authorHui, ES-
dc.contributor.authorCao, P-
dc.date.accessioned2021-10-20T10:07:38Z-
dc.date.available2021-10-20T10:07:38Z-
dc.date.issued2021-
dc.identifier.citationMagnetic Resonance Imaging, 2021, v. 81, p. 82-87-
dc.identifier.issn0730-725X-
dc.identifier.urihttp://hdl.handle.net/10722/305312-
dc.description.abstractPurpose: This study aimed at introducing short-T1/T2 compartment to MR fingerprinting (MRF) at 3 T. Water that is bound to myelin macromolecules have significantly shorter T1 and T2 than free water and can be distinguished from free water by multi-compartment analysis. Methods: We developed a new multi-inversion-recovery (mIR) water mapping-MRF based on an unbalanced steady-state coherent sequence (FISP). mIR pulses with an interval of 400 or 500 repetition times (TRs) were inserted into the conventional FISP MRF sequence. Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting. Three healthy volunteers were scanned with mIR MRF on a clinical 3 T MRI. Results: Using an extended phase graph simulation, we found that our proposed mIR scheme with four IR pulses allowed differentiation between short and long T1/T2 components. For in vivo experiments, we achieved the quantification of myelin water, gray matter water, and white matter water at an image resolution of 1.17 × 1.17 × 5 mm3/pixel. As compared to the conventional MRF technique with single IR, our proposed mIR improved the detection of myelin water content. In addition, mIR MRF using spiral-in/out trajectory provided a higher signal level compared with that with spiral-out trajectory. Myelin water quantification using mIR MRF with 4 IR and 5 IR pulses were qualitatively similar. Meanwhile, 5 IR MRF showed fewer artifacts in myelin water detection. Conclusion: We developed a new mIR MRF sequence for the rapid quantification of brain water compartments.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri-
dc.relation.ispartofMagnetic Resonance Imaging-
dc.subjectMyelin-
dc.subjectBrain MRI-
dc.subjectMulti-contrast MRI-
dc.subjectMR fingerprinting-
dc.titleA multi-inversion-recovery magnetic resonance fingerprinting for multi-compartment water mapping-
dc.typeArticle-
dc.identifier.emailCao, P: caopeng1@hku.hk-
dc.identifier.authorityCao, P=rp02474-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mri.2021.06.005-
dc.identifier.pmid34146651-
dc.identifier.scopuseid_2-s2.0-85108404026-
dc.identifier.hkuros326785-
dc.identifier.volume81-
dc.identifier.spage82-
dc.identifier.epage87-
dc.identifier.isiWOS:000668251800011-
dc.publisher.placeUnited States-

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