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- Publisher Website: 10.1039/D0CY02442B
- Scopus: eid_2-s2.0-85107014999
- WOS: WOS:000634893700001
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Article: Additive-free N-methylation of amines with methanol over supported iridium catalyst
Title | Additive-free N-methylation of amines with methanol over supported iridium catalyst |
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Authors | |
Issue Date | 2021 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/CY#!recentarticles&all |
Citation | Catalysis Science & Technology, 2021, v. 11 n. 10, p. 3364-3375 How to Cite? |
Abstract | An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-free N-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+ and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOx and ZnO support also promoted its high reactivity. The selectivity of this catalytic N-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation of N,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production of N-methylated amines. With optimal flow rates and amine concentrations, a variety of N-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production of N-methylamines with this cost-effective chemical process. |
Persistent Identifier | http://hdl.handle.net/10722/305279 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.050 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, J | - |
dc.contributor.author | Qiang, W | - |
dc.contributor.author | Ye, S | - |
dc.contributor.author | Zhu, L | - |
dc.contributor.author | Liu, X | - |
dc.contributor.author | Loh, TP | - |
dc.date.accessioned | 2021-10-20T10:07:10Z | - |
dc.date.available | 2021-10-20T10:07:10Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Catalysis Science & Technology, 2021, v. 11 n. 10, p. 3364-3375 | - |
dc.identifier.issn | 2044-4753 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305279 | - |
dc.description.abstract | An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-free N-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+ and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOx and ZnO support also promoted its high reactivity. The selectivity of this catalytic N-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation of N,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production of N-methylated amines. With optimal flow rates and amine concentrations, a variety of N-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production of N-methylamines with this cost-effective chemical process. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/CY#!recentarticles&all | - |
dc.relation.ispartof | Catalysis Science & Technology | - |
dc.title | Additive-free N-methylation of amines with methanol over supported iridium catalyst | - |
dc.type | Article | - |
dc.identifier.email | Ye, S: yesen@hku.hk | - |
dc.identifier.authority | Ye, S=rp02805 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/D0CY02442B | - |
dc.identifier.scopus | eid_2-s2.0-85107014999 | - |
dc.identifier.hkuros | 327332 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 3364 | - |
dc.identifier.epage | 3375 | - |
dc.identifier.isi | WOS:000634893700001 | - |
dc.publisher.place | United Kingdom | - |