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Article: Advances in Antimicrobial Microneedle Patches for Combating Infections

TitleAdvances in Antimicrobial Microneedle Patches for Combating Infections
Authors
Keywordsantibacterial microneedles
antifungal patches
antiviral microneedles
ocular microneedle patches
transdermal drug delivery
Issue Date2020
PublisherWiley-VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089
Citation
Advanced Materials, 2020, v. 32 n. 33, p. article no. 2002129 How to Cite?
AbstractSkin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/305259
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJamaledin, R-
dc.contributor.authorYiu, CKY-
dc.contributor.authorZare, EN-
dc.contributor.authorNiu, LN-
dc.contributor.authorVecchione, R-
dc.contributor.authorChen, G-
dc.contributor.authorGu, Z-
dc.contributor.authorTay, FR-
dc.contributor.authorMakvandi, P-
dc.date.accessioned2021-10-20T10:06:53Z-
dc.date.available2021-10-20T10:06:53Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Materials, 2020, v. 32 n. 33, p. article no. 2002129-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/305259-
dc.description.abstractSkin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.-
dc.languageeng-
dc.publisherWiley-VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089-
dc.relation.ispartofAdvanced Materials-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectantibacterial microneedles-
dc.subjectantifungal patches-
dc.subjectantiviral microneedles-
dc.subjectocular microneedle patches-
dc.subjecttransdermal drug delivery-
dc.titleAdvances in Antimicrobial Microneedle Patches for Combating Infections-
dc.typeArticle-
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hk-
dc.identifier.emailTay, FR: franktay@hkucc.hku.hk-
dc.identifier.authorityYiu, CKY=rp00018-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.202002129-
dc.identifier.pmid32602146-
dc.identifier.scopuseid_2-s2.0-85087291088-
dc.identifier.hkuros328317-
dc.identifier.volume32-
dc.identifier.issue33-
dc.identifier.spagearticle no. 2002129-
dc.identifier.epagearticle no. 2002129-
dc.identifier.isiWOS:000543970500001-
dc.publisher.placeGermany-

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