File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Associations between salivary cytokines and periodontal and microbiological parameters in orthodontic patients

TitleAssociations between salivary cytokines and periodontal and microbiological parameters in orthodontic patients
Authors
Issue Date2021
PublisherLippincott, Williams & Wilkins: Various Creative Commons. The Journal's web site is located at http://journals.lww.com/md-journal/pages/default.aspx
Citation
Medicine, 2021, v. 100 n. 10, p. e24924 How to Cite?
AbstractOrthodontic treatment can lead to microbial-induced gingival inflammation and aseptic periodontal inflammations. The aim of this study was to investigate the relationship between salivary pro-inflammatory cytokines levels with gingival health status and oral microbe loads among patients undergoing orthodontic treatment. The present investigation was a cross-sectional study among a sample of 111 consecutive orthodontic patients (mean age 18.4 ± 4.4 years). Clinical examinations were conducted to assess the gingival health status employing the Modified Gingival Index, Gingival Bleeding Index, and Plaque Index. Salivary microbiological assessments of total aerobic and anaerobic bacteria count, streptococci count, and lactobacilli count were undertaken. Saliva immunological assessments included Interleukin-1Beta (IL-1β) and macrophage migration inhibitory factor (MIF) ELISA assays. The mean ± standard deviation of salivary IL-1β was 83.52 ± 85.62 pg/ml and MIF was 4.12 ± 0.96 ng/ml. Moderate positive correlations were found between salivary IL-1β levels and total aerobic and anaerobic bacteria count, streptococci count, and lactobacilli count (r = 0.380–0.446, P < .001), and weak positive correlations between salivary MIF levels and total salivary aerobic and anaerobic bacteria counts (r = 0.249–0.306, P < .01) were observed. A positive correlation was found between salivary IL-1β levels and Bleeding Index (r = 0.216, P < .05). The level of salivary IL-1β positively correlates with oral bacterial load among orthodontic patients; the relationship between inflammatory cytokines and oral microflora deserved further study.
Persistent Identifierhttp://hdl.handle.net/10722/305252
ISSN
2023 Impact Factor: 1.3
2023 SCImago Journal Rankings: 0.441
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Y-
dc.contributor.authorWong, WK-
dc.contributor.authorSeneviratne, JC-
dc.contributor.authorHuang, S-
dc.contributor.authorMcGrath, C-
dc.contributor.authorHagg, EUO-
dc.date.accessioned2021-10-20T10:06:48Z-
dc.date.available2021-10-20T10:06:48Z-
dc.date.issued2021-
dc.identifier.citationMedicine, 2021, v. 100 n. 10, p. e24924-
dc.identifier.issn0025-7974-
dc.identifier.urihttp://hdl.handle.net/10722/305252-
dc.description.abstractOrthodontic treatment can lead to microbial-induced gingival inflammation and aseptic periodontal inflammations. The aim of this study was to investigate the relationship between salivary pro-inflammatory cytokines levels with gingival health status and oral microbe loads among patients undergoing orthodontic treatment. The present investigation was a cross-sectional study among a sample of 111 consecutive orthodontic patients (mean age 18.4 ± 4.4 years). Clinical examinations were conducted to assess the gingival health status employing the Modified Gingival Index, Gingival Bleeding Index, and Plaque Index. Salivary microbiological assessments of total aerobic and anaerobic bacteria count, streptococci count, and lactobacilli count were undertaken. Saliva immunological assessments included Interleukin-1Beta (IL-1β) and macrophage migration inhibitory factor (MIF) ELISA assays. The mean ± standard deviation of salivary IL-1β was 83.52 ± 85.62 pg/ml and MIF was 4.12 ± 0.96 ng/ml. Moderate positive correlations were found between salivary IL-1β levels and total aerobic and anaerobic bacteria count, streptococci count, and lactobacilli count (r = 0.380–0.446, P < .001), and weak positive correlations between salivary MIF levels and total salivary aerobic and anaerobic bacteria counts (r = 0.249–0.306, P < .01) were observed. A positive correlation was found between salivary IL-1β levels and Bleeding Index (r = 0.216, P < .05). The level of salivary IL-1β positively correlates with oral bacterial load among orthodontic patients; the relationship between inflammatory cytokines and oral microflora deserved further study.-
dc.languageeng-
dc.publisherLippincott, Williams & Wilkins: Various Creative Commons. The Journal's web site is located at http://journals.lww.com/md-journal/pages/default.aspx-
dc.relation.ispartofMedicine-
dc.titleAssociations between salivary cytokines and periodontal and microbiological parameters in orthodontic patients-
dc.typeArticle-
dc.identifier.emailMcGrath, C: mcgrathc@hkucc.hku.hk-
dc.identifier.authorityMcGrath, C=rp00037-
dc.identifier.authorityHagg, EUO=rp00020-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/MD.0000000000024924-
dc.identifier.pmid33725852-
dc.identifier.pmcidPMC7969212-
dc.identifier.hkuros326878-
dc.identifier.volume100-
dc.identifier.issue10-
dc.identifier.spagee24924-
dc.identifier.epagee24924-
dc.identifier.isiWOS:000659034600046-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats