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Article: SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

TitleSARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 4678 How to Cite?
AbstractSARS-CoV-2 infection of children leads to a mild illness and the immunological differences with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection. Infected children have lower CD4+ and CD8+ T cell responses to SARS-CoV-2 structural and ORF1ab proteins when compared with infected adults, comparable T cell polyfunctionality and reduced CD4+ T cell effector memory. Compared with adults, children have lower levels of antibodies to β-coronaviruses, indicating differing baseline immunity. Total T follicular helper responses are increased, whilst monocyte numbers are reduced, indicating rapid adaptive co-ordination of the T and B cell responses and differing levels of inflammation. Therefore, reduced prior β-coronavirus immunity and reduced T cell activation in children might drive milder COVID-19 pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/305185
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCohen, CA-
dc.contributor.authorLi, APY-
dc.contributor.authorHachim, A-
dc.contributor.authorHui, DSC-
dc.contributor.authorKwan, MYW-
dc.contributor.authorTsang, QTY-
dc.contributor.authorChiu, SS-
dc.contributor.authorChan, WH-
dc.contributor.authorYau, YS-
dc.contributor.authorKavian-Tessler, N-
dc.contributor.authorMa, FNL-
dc.contributor.authorLau, EHY-
dc.contributor.authorCheng, SMS-
dc.contributor.authorPoon, LLM-
dc.contributor.authorPeiris, M-
dc.contributor.authorValkenburg , SA-
dc.date.accessioned2021-10-20T10:05:49Z-
dc.date.available2021-10-20T10:05:49Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 4678-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/305185-
dc.description.abstractSARS-CoV-2 infection of children leads to a mild illness and the immunological differences with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection. Infected children have lower CD4+ and CD8+ T cell responses to SARS-CoV-2 structural and ORF1ab proteins when compared with infected adults, comparable T cell polyfunctionality and reduced CD4+ T cell effector memory. Compared with adults, children have lower levels of antibodies to β-coronaviruses, indicating differing baseline immunity. Total T follicular helper responses are increased, whilst monocyte numbers are reduced, indicating rapid adaptive co-ordination of the T and B cell responses and differing levels of inflammation. Therefore, reduced prior β-coronavirus immunity and reduced T cell activation in children might drive milder COVID-19 pathogenesis.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection-
dc.typeArticle-
dc.identifier.emailHachim, A: ahachim@hku.hk-
dc.identifier.emailChiu, SS: ssschiu@hku.hk-
dc.identifier.emailMa, FNL: fionnma@hku.hk-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailCheng, SMS: samuelms@hku.hk-
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hk-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.emailValkenburg , SA: sophiev@hku.hk-
dc.identifier.authorityChiu, SS=rp00421-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityPoon, LLM=rp00484-
dc.identifier.authorityPeiris, M=rp00410-
dc.identifier.authorityValkenburg , SA=rp02141-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-24938-4-
dc.identifier.pmid34326343-
dc.identifier.pmcidPMC8322064-
dc.identifier.scopuseid_2-s2.0-85111531468-
dc.identifier.hkuros327835-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 4678-
dc.identifier.epagearticle no. 4678-
dc.identifier.isiWOS:000681060100002-
dc.publisher.placeUnited Kingdom-

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