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Article: Adiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis

TitleAdiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis
Authors
Keywordsadiponectin
B cells
proliferation
differentiation
collagen-induced arthritis
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2021, v. 12, p. article no. 626310 How to Cite?
AbstractAlthough B cells have been shown to contribute to the pathogenesis of rheumatoid arthritis (RA), the precise role of B cells in RA needs to be explored further. Our previous studies have revealed that adiponectin (AD) is expressed at high levels in inflamed synovial joint tissues, and its expression is closely correlated with progressive bone erosion in patients with RA. In this study, we investigated the possible role of AD in B cell proliferation and differentiation. We found that AD stimulation could induce B cell proliferation and differentiation in cell culture. Notably, local intraarticular injection of AD promoted B cell expansion in joint tissues and exacerbated arthritis in mice with collagen-induced arthritis (CIA). Mechanistically, AD induced the activation of PI3K/Akt1 and STAT3 and promoted the proliferation and differentiation of B cells. Moreover, STAT3 bound to the promoter of the Blimp-1 gene, upregulated Blimp-1 expression at the transcriptional level, and promoted B cell differentiation. Collectively, we observed that AD exacerbated CIA by enhancing B cell proliferation and differentiation mediated by the PI3K/Akt1/STAT3 axis.
Persistent Identifierhttp://hdl.handle.net/10722/305080
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 1.868
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChe, N-
dc.contributor.authorSun, X-
dc.contributor.authorGu, LEI-
dc.contributor.authorWang, X-
dc.contributor.authorShi, J-
dc.contributor.authorSun, Y-
dc.contributor.authorXu, L-
dc.contributor.authorLiu, R-
dc.contributor.authorWang, J-
dc.contributor.authorZhu, F-
dc.contributor.authorPeng, N-
dc.contributor.authorXiao, F-
dc.contributor.authorHu, D-
dc.contributor.authorLu, L-
dc.contributor.authorQiu, W-
dc.contributor.authorZhang, M-
dc.date.accessioned2021-10-05T02:39:27Z-
dc.date.available2021-10-05T02:39:27Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Immunology, 2021, v. 12, p. article no. 626310-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/305080-
dc.description.abstractAlthough B cells have been shown to contribute to the pathogenesis of rheumatoid arthritis (RA), the precise role of B cells in RA needs to be explored further. Our previous studies have revealed that adiponectin (AD) is expressed at high levels in inflamed synovial joint tissues, and its expression is closely correlated with progressive bone erosion in patients with RA. In this study, we investigated the possible role of AD in B cell proliferation and differentiation. We found that AD stimulation could induce B cell proliferation and differentiation in cell culture. Notably, local intraarticular injection of AD promoted B cell expansion in joint tissues and exacerbated arthritis in mice with collagen-induced arthritis (CIA). Mechanistically, AD induced the activation of PI3K/Akt1 and STAT3 and promoted the proliferation and differentiation of B cells. Moreover, STAT3 bound to the promoter of the Blimp-1 gene, upregulated Blimp-1 expression at the transcriptional level, and promoted B cell differentiation. Collectively, we observed that AD exacerbated CIA by enhancing B cell proliferation and differentiation mediated by the PI3K/Akt1/STAT3 axis.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadiponectin-
dc.subjectB cells-
dc.subjectproliferation-
dc.subjectdifferentiation-
dc.subjectcollagen-induced arthritis-
dc.titleAdiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis-
dc.typeArticle-
dc.identifier.emailWang, X: xiaohuiwang@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityWang, X=rp02664-
dc.identifier.authorityXiao, F=rp02664-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2021.626310-
dc.identifier.pmid33815378-
dc.identifier.pmcidPMC8012765-
dc.identifier.scopuseid_2-s2.0-85103522317-
dc.identifier.hkuros326219-
dc.identifier.volume12-
dc.identifier.spagearticle no. 626310-
dc.identifier.epagearticle no. 626310-
dc.identifier.isiWOS:000635565700001-
dc.publisher.placeSwitzerland-

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