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Conference Paper: Development of cisplatin-loaded poly (ethylene glycol) and gelatin-based hydrogels for transarterial chemoembolization in a mouse model of orthotopic liver cancer

TitleDevelopment of cisplatin-loaded poly (ethylene glycol) and gelatin-based hydrogels for transarterial chemoembolization in a mouse model of orthotopic liver cancer
Authors
Issue Date2018
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
The 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018. In Transplantation, 2018, v. 102 n. 5S, p. 181-182, abstract no. P-215 How to Cite?
AbstractBackground: Transarterial Chemoembolization was introduced as a palliative treatment for patients with unresectable HCC. However, the drug delivery system seems to be inconsistent and unstable in maintaining a high concentration of drugs at tumor sites. This study evaluated the embolic activity and anti-tumor effects of poly (ethylene glycol) diacrylate (PEGdA) and thiolated gelatin poly (ethylene glycol) (Gel-PEG-Cys) cross-linked hydrogels loaded with cisplatin in vivo HCC models. Methods: The delivery system is UV-sensitive hydrogels containing a chemotherapeutic drug (cisplatin). Hydrogels were made at 0.5%(w/v) photoinitiator, 10% (w/v) PEGdA, and 10% (w/v) Gel-PEG-Cys. The nude mice with orthotopic liver tumor (developed from MHCC97L cell line, located at the left lobe) were injected with hydrogels from the left branch of portal vein with the exposure of UV light. Then the development of tumor in mice were visualized using in vivo imaging system (Perkin Elmer IVIS Spectrum). The anti-tumor capacities and the associated mechanism were further explored. Results: Severe liver damage was induced by lack of blood supply without cardiovascular nor pulmonary embolism in nude mice after hydrogel injection (Fig.A). In addition, hydrogels were found blocking in the tiny branches of portal vein around the tumor area. Cisplatin-loaded hydrogels significantly decreased the development of HCC compared to the control (Fig.B). Mice treated with cisplatin-loaded hydrogels exhibited a significant 1.8-fold decrease in signal intensity of HCC tumor compared to the control (P=0.024) after 4 weeks (Fig.C).
Persistent Identifierhttp://hdl.handle.net/10722/304971
ISSN
2021 Impact Factor: 5.385
2020 SCImago Journal Rankings: 1.450

 

DC FieldValueLanguage
dc.contributor.authorYang, XX-
dc.contributor.authorYeung, OWH-
dc.contributor.authorLo, CM-
dc.contributor.authorKao, WJ-
dc.contributor.authorMan, K-
dc.date.accessioned2021-10-05T02:37:52Z-
dc.date.available2021-10-05T02:37:52Z-
dc.date.issued2018-
dc.identifier.citationThe 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018. In Transplantation, 2018, v. 102 n. 5S, p. 181-182, abstract no. P-215-
dc.identifier.issn0041-1337-
dc.identifier.urihttp://hdl.handle.net/10722/304971-
dc.description.abstractBackground: Transarterial Chemoembolization was introduced as a palliative treatment for patients with unresectable HCC. However, the drug delivery system seems to be inconsistent and unstable in maintaining a high concentration of drugs at tumor sites. This study evaluated the embolic activity and anti-tumor effects of poly (ethylene glycol) diacrylate (PEGdA) and thiolated gelatin poly (ethylene glycol) (Gel-PEG-Cys) cross-linked hydrogels loaded with cisplatin in vivo HCC models. Methods: The delivery system is UV-sensitive hydrogels containing a chemotherapeutic drug (cisplatin). Hydrogels were made at 0.5%(w/v) photoinitiator, 10% (w/v) PEGdA, and 10% (w/v) Gel-PEG-Cys. The nude mice with orthotopic liver tumor (developed from MHCC97L cell line, located at the left lobe) were injected with hydrogels from the left branch of portal vein with the exposure of UV light. Then the development of tumor in mice were visualized using in vivo imaging system (Perkin Elmer IVIS Spectrum). The anti-tumor capacities and the associated mechanism were further explored. Results: Severe liver damage was induced by lack of blood supply without cardiovascular nor pulmonary embolism in nude mice after hydrogel injection (Fig.A). In addition, hydrogels were found blocking in the tiny branches of portal vein around the tumor area. Cisplatin-loaded hydrogels significantly decreased the development of HCC compared to the control (Fig.B). Mice treated with cisplatin-loaded hydrogels exhibited a significant 1.8-fold decrease in signal intensity of HCC tumor compared to the control (P=0.024) after 4 weeks (Fig.C).-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com-
dc.relation.ispartofTransplantation-
dc.relation.ispartofThe 2018 Joint International Congress of ILTS, ELITA & LICAGE-
dc.titleDevelopment of cisplatin-loaded poly (ethylene glycol) and gelatin-based hydrogels for transarterial chemoembolization in a mouse model of orthotopic liver cancer-
dc.typeConference_Paper-
dc.identifier.emailKao, WJ: wjkao@hku.hk-
dc.identifier.authorityKao, WJ=rp02076-
dc.identifier.hkuros326391-
dc.identifier.volume102-
dc.identifier.issue5S-
dc.identifier.spage181-
dc.identifier.epage182-
dc.publisher.placeUnited States-
dc.identifier.partofdoi10.1097/01.tp.0000534078.18014.88-

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