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- Publisher Website: 10.3390/bioengineering8020017
- Scopus: eid_2-s2.0-85100527810
- PMID: 33494220
- WOS: WOS:000622103900001
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Article: Navigating the collagen jungle: the biomedical potential of fiber organization in cancer
Title | Navigating the collagen jungle: the biomedical potential of fiber organization in cancer |
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Authors | |
Keywords | ECM cancer extracellular matrix fibrillar collagen pathology |
Issue Date | 2021 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/bioengineering |
Citation | Bioengineering, 2021, v. 8 n. 2, p. article no. 17 How to Cite? |
Abstract | Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include collagen fiber evaluation as part of the investigation of cancer development and progression. Fibrillar collagen is the most abundant in the normal extracellular matrix, and was revealed to be upregulated in many cancers. Recent studies suggested an emerging theme across multiple cancer types in which specific collagen fiber organization patterns differ between benign and malignant tissue and also appear to be associated with disease stage, prognosis, treatment response, and other clinical features. There is great potential for developing image-based collagen fiber biomarkers for clinical applications, but its adoption in standard clinical practice is dependent on further translational and clinical evaluations. Here, we offer a comprehensive review of the current literature of fibrillar collagen structure and organization as a candidate cancer biomarker, and new perspectives on the challenges and next steps for researchers and clinicians seeking to exploit this information in biomedical research and clinical workflows. |
Persistent Identifier | http://hdl.handle.net/10722/304968 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.627 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kao, WJ | - |
dc.date.accessioned | 2021-10-05T02:37:50Z | - |
dc.date.available | 2021-10-05T02:37:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Bioengineering, 2021, v. 8 n. 2, p. article no. 17 | - |
dc.identifier.issn | 2306-5354 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304968 | - |
dc.description.abstract | Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include collagen fiber evaluation as part of the investigation of cancer development and progression. Fibrillar collagen is the most abundant in the normal extracellular matrix, and was revealed to be upregulated in many cancers. Recent studies suggested an emerging theme across multiple cancer types in which specific collagen fiber organization patterns differ between benign and malignant tissue and also appear to be associated with disease stage, prognosis, treatment response, and other clinical features. There is great potential for developing image-based collagen fiber biomarkers for clinical applications, but its adoption in standard clinical practice is dependent on further translational and clinical evaluations. Here, we offer a comprehensive review of the current literature of fibrillar collagen structure and organization as a candidate cancer biomarker, and new perspectives on the challenges and next steps for researchers and clinicians seeking to exploit this information in biomedical research and clinical workflows. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/bioengineering | - |
dc.relation.ispartof | Bioengineering | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | ECM | - |
dc.subject | cancer | - |
dc.subject | extracellular matrix | - |
dc.subject | fibrillar collagen | - |
dc.subject | pathology | - |
dc.title | Navigating the collagen jungle: the biomedical potential of fiber organization in cancer | - |
dc.type | Article | - |
dc.identifier.email | Kao, WJ: wjkao@hku.hk | - |
dc.identifier.authority | Kao, WJ=rp02076 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/bioengineering8020017 | - |
dc.identifier.pmid | 33494220 | - |
dc.identifier.pmcid | PMC7909776 | - |
dc.identifier.scopus | eid_2-s2.0-85100527810 | - |
dc.identifier.hkuros | 326385 | - |
dc.identifier.hkuros | 326386 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | article no. 17 | - |
dc.identifier.epage | article no. 17 | - |
dc.identifier.isi | WOS:000622103900001 | - |
dc.publisher.place | Switzerland | - |