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Article: Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis
Title | Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis |
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Authors | |
Keywords | Hepatoprotective Anti-angiogenic effect Osbeckia octandra Wistar rats Thioacetamide Cirrhosis |
Issue Date | 2021 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules |
Citation | Molecules, 2021, v. 26 n. 16, article no. 4836 How to Cite? |
Abstract | Chronic liver inflammation has become a major global health concern. In the absence of clinical surrogate markers to diagnose inflammatory liver disease, the intervention with effective drugs in modern medicine tends to be late. In Sri Lanka, traditional medical practitioners prescribe herbal preparations from Osbeckia octandra for the prevention and treatment of liver disorders. To test the efficacy of such treatments, we have administered thioacetamide (TAA) to male Wistar rats to induce chronic liver damage (disease control; DC) and examined how various leaf extracts: crude leaf suspension (CLS), boiled leaf extract (BLE), sonicated leaf extract (SLE), methanol leaf extract (MLE) and hexane leaf extract (HLE) of O. octandra ameliorate TAA-induced liver disease. The CLS, BLE and SLE treatments in cirrhotic rats significantly attenuated disease-related changes, such as liver weight and hepato-enzymes. The mRNA levels of Tnf-α were significantly decreased by 3.6, 10 and 3.9 times in CLS, BLE and SLE compared to DC. The same treatments resulted in significantly lower (19.5, 4.2 and 2.4 times) α-Sma levels compared to DC. In addition, Tgf-β1 and Vegf-R2 mRNA expressions were significantly lower with the treatments. Moreover, BLE expressed a strong anti-angiogenic effect. We conclude that CLS, BLE and SLE from O. octandra have potent hepatic anti-fibrotic effects in TAA-induced liver cirrhosis. |
Persistent Identifier | http://hdl.handle.net/10722/304927 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 0.744 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bogahawaththa, S | - |
dc.contributor.author | Kodithuwakku, SP | - |
dc.contributor.author | Wijesundera, KK | - |
dc.contributor.author | Siriweera, EH | - |
dc.contributor.author | Jayasinghe, L | - |
dc.contributor.author | Dissanayaka, WL | - |
dc.contributor.author | Rajapakse, J | - |
dc.contributor.author | Herath, CB | - |
dc.contributor.author | Tsujita, T | - |
dc.contributor.author | Wijayagunawardane, MPB | - |
dc.date.accessioned | 2021-10-05T02:37:14Z | - |
dc.date.available | 2021-10-05T02:37:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Molecules, 2021, v. 26 n. 16, article no. 4836 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304927 | - |
dc.description.abstract | Chronic liver inflammation has become a major global health concern. In the absence of clinical surrogate markers to diagnose inflammatory liver disease, the intervention with effective drugs in modern medicine tends to be late. In Sri Lanka, traditional medical practitioners prescribe herbal preparations from Osbeckia octandra for the prevention and treatment of liver disorders. To test the efficacy of such treatments, we have administered thioacetamide (TAA) to male Wistar rats to induce chronic liver damage (disease control; DC) and examined how various leaf extracts: crude leaf suspension (CLS), boiled leaf extract (BLE), sonicated leaf extract (SLE), methanol leaf extract (MLE) and hexane leaf extract (HLE) of O. octandra ameliorate TAA-induced liver disease. The CLS, BLE and SLE treatments in cirrhotic rats significantly attenuated disease-related changes, such as liver weight and hepato-enzymes. The mRNA levels of Tnf-α were significantly decreased by 3.6, 10 and 3.9 times in CLS, BLE and SLE compared to DC. The same treatments resulted in significantly lower (19.5, 4.2 and 2.4 times) α-Sma levels compared to DC. In addition, Tgf-β1 and Vegf-R2 mRNA expressions were significantly lower with the treatments. Moreover, BLE expressed a strong anti-angiogenic effect. We conclude that CLS, BLE and SLE from O. octandra have potent hepatic anti-fibrotic effects in TAA-induced liver cirrhosis. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules | - |
dc.relation.ispartof | Molecules | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Hepatoprotective | - |
dc.subject | Anti-angiogenic effect | - |
dc.subject | Osbeckia octandra | - |
dc.subject | Wistar rats | - |
dc.subject | Thioacetamide | - |
dc.subject | Cirrhosis | - |
dc.title | Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis | - |
dc.type | Article | - |
dc.identifier.email | Dissanayaka, WL: warunad@hku.hk | - |
dc.identifier.authority | Dissanayaka, WL=rp02216 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/molecules26164836 | - |
dc.identifier.pmid | 34443423 | - |
dc.identifier.pmcid | PMC8401385 | - |
dc.identifier.scopus | eid_2-s2.0-85112582567 | - |
dc.identifier.hkuros | 326182 | - |
dc.identifier.volume | 26 | - |
dc.identifier.issue | 16 | - |
dc.identifier.spage | article no. 4836 | - |
dc.identifier.epage | article no. 4836 | - |
dc.identifier.isi | WOS:000689874900001 | - |
dc.publisher.place | Switzerland | - |