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Article: Green Light-Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma

TitleGreen Light-Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma
Authors
KeywordsLight-triggered drug release
Ocular drug delivery
Retinoblastoma
Self-assembly
Trigonal small molecules
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2021, v. 8 n. 20, article no. 2101754 How to Cite?
AbstractRetinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also less efficient for ocular drug delivery because of the existence of blood-retinal barrier and systemic side effects. Here, a photoresponsive drug release system is reported, which is self-assembled from photocleavable trigonal small molecules, to achieve light-triggered intraocular drug accumulation. After intravenous injection of drug-loaded nanocarriers, green light can trigger the disassembly of the nanocarriers in retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth. This proof-of-concept study would advance the development of light-triggered drug release systems for the intravenous treatment of eye diseases.
Persistent Identifierhttp://hdl.handle.net/10722/304895
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 3.914
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLong, K-
dc.contributor.authorYang, Y-
dc.contributor.authorLv, W-
dc.contributor.authorJiang, K-
dc.contributor.authorLi, Y-
dc.contributor.authorLo, ACY-
dc.contributor.authorLam, WC-
dc.contributor.authorZhan, C-
dc.contributor.authorWang, W-
dc.date.accessioned2021-10-05T02:36:45Z-
dc.date.available2021-10-05T02:36:45Z-
dc.date.issued2021-
dc.identifier.citationAdvanced Science, 2021, v. 8 n. 20, article no. 2101754-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/304895-
dc.description.abstractRetinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also less efficient for ocular drug delivery because of the existence of blood-retinal barrier and systemic side effects. Here, a photoresponsive drug release system is reported, which is self-assembled from photocleavable trigonal small molecules, to achieve light-triggered intraocular drug accumulation. After intravenous injection of drug-loaded nanocarriers, green light can trigger the disassembly of the nanocarriers in retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth. This proof-of-concept study would advance the development of light-triggered drug release systems for the intravenous treatment of eye diseases.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLight-triggered drug release-
dc.subjectOcular drug delivery-
dc.subjectRetinoblastoma-
dc.subjectSelf-assembly-
dc.subjectTrigonal small molecules-
dc.titleGreen Light-Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma-
dc.typeArticle-
dc.identifier.emailLo, ACY: amylo@hku.hk-
dc.identifier.emailLam, WC: waichlam@hku.hk-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityLo, ACY=rp00425-
dc.identifier.authorityLam, WC=rp02162-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.202101754-
dc.identifier.pmid34448360-
dc.identifier.pmcidPMC8529428-
dc.identifier.scopuseid_2-s2.0-85113695414-
dc.identifier.hkuros326547-
dc.identifier.volume8-
dc.identifier.issue20-
dc.identifier.spagearticle no. 2101754-
dc.identifier.epagearticle no. 2101754-
dc.identifier.isiWOS:000689704300001-
dc.publisher.placeGermany-

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