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- Publisher Website: 10.1002/oby.22469
- Scopus: eid_2-s2.0-85065461665
- PMID: 31067017
- WOS: WOS:000468798100022
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Article: Sleep duration and adiposity in children and adults: observational and mendelian randomization studies
Title | Sleep duration and adiposity in children and adults: observational and mendelian randomization studies |
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Authors | |
Issue Date | 2019 |
Publisher | Wiley-Blackwell Publishing, Inc. |
Citation | Obesity, 2019, v. 27 n. 6, p. 1013-1022 How to Cite? |
Abstract | Objective:
This study used two complementary designs, an observational and a Mendelian randomization (MR) study, to assess whether sleep duration causes adiposity in children and adults.
Methods:
In Hong Kong's “Children of 1997” birth cohort, the adjusted cross-sectional associations of sleep duration with BMI z score and obesity and overweight were assessed at ~11 years of age. Generalized estimating equations were also used to examine longitudinal associations of sleep duration at ~11 years with annual BMI z score and obesity and overweight at about 11 to 16 years of age. Using MR, this study assessed the association of genetically predicted sleep duration, based on 54 single-nucleotide polymorphisms, applied to genetic studies of adiposity in children (n = 35,668), men (n = 152,893), and women (n = 171,977).
Results:
Longer sleep was cross-sectionally associated with lower BMI z score at ~11 years of age (−0.13 per category, 95% CI: −0.22 to −0.04) and at about 11 to 16 years of age longitudinally in girls (−0.39, 95% CI: −0.66 to −0.13). Using MR, sleep duration was inversely associated with BMI in children (−0.29 SD per hour, 95% CI: −0.54 to −0.04), but was not clearly associated with BMI in adults, particularly for women.
Conclusions:
A small beneficial effect of sleep on BMI in children cannot be ruled out. |
Persistent Identifier | http://hdl.handle.net/10722/304878 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.586 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WANG, J | - |
dc.contributor.author | Li, AM | - |
dc.contributor.author | L, HS | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Schooling, CM | - |
dc.date.accessioned | 2021-10-05T02:36:31Z | - |
dc.date.available | 2021-10-05T02:36:31Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Obesity, 2019, v. 27 n. 6, p. 1013-1022 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304878 | - |
dc.description.abstract | Objective: This study used two complementary designs, an observational and a Mendelian randomization (MR) study, to assess whether sleep duration causes adiposity in children and adults. Methods: In Hong Kong's “Children of 1997” birth cohort, the adjusted cross-sectional associations of sleep duration with BMI z score and obesity and overweight were assessed at ~11 years of age. Generalized estimating equations were also used to examine longitudinal associations of sleep duration at ~11 years with annual BMI z score and obesity and overweight at about 11 to 16 years of age. Using MR, this study assessed the association of genetically predicted sleep duration, based on 54 single-nucleotide polymorphisms, applied to genetic studies of adiposity in children (n = 35,668), men (n = 152,893), and women (n = 171,977). Results: Longer sleep was cross-sectionally associated with lower BMI z score at ~11 years of age (−0.13 per category, 95% CI: −0.22 to −0.04) and at about 11 to 16 years of age longitudinally in girls (−0.39, 95% CI: −0.66 to −0.13). Using MR, sleep duration was inversely associated with BMI in children (−0.29 SD per hour, 95% CI: −0.54 to −0.04), but was not clearly associated with BMI in adults, particularly for women. Conclusions: A small beneficial effect of sleep on BMI in children cannot be ruled out. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing, Inc. | - |
dc.relation.ispartof | Obesity | - |
dc.rights | Submitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.title | Sleep duration and adiposity in children and adults: observational and mendelian randomization studies | - |
dc.type | Article | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/oby.22469 | - |
dc.identifier.pmid | 31067017 | - |
dc.identifier.scopus | eid_2-s2.0-85065461665 | - |
dc.identifier.hkuros | 325820 | - |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1013 | - |
dc.identifier.epage | 1022 | - |
dc.identifier.isi | WOS:000468798100022 | - |
dc.publisher.place | United States | - |