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Article: Placenta-Derived Exosomes as a Modulator in Maternal Immune Tolerance During Pregnancy

TitlePlacenta-Derived Exosomes as a Modulator in Maternal Immune Tolerance During Pregnancy
Authors
Keywordsplacenta
exosomes
maternal immune tolerance
preeclampsia
gestational diabetes mellitus
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2021, v. 12, p. article no. 671093 How to Cite?
AbstractExosomes are a subset of extracellular vesicles with an average diameter of ~100nm. Exosomes are released by all cells through an endosome-dependent pathway and carry nucleic acids, proteins, lipids, cytokines and metabolites, mirroring the state of the originating cells. The function of exosomes has been implicated in various reproduction processes, such as embryo development, implantation, decidualization and placentation. Placenta-derived exosomes (pEXO) can be detected in the maternal blood as early as 6 weeks after conception and their levels increase with gestational age. Importantly, alternations in the molecular signatures of pEXO are observed in pregnancy-related complications. Thus, these differentially expressed molecules could be the potential biomarkers for diagnosis of the pregnancy-associated diseases. Recent studies have demonstrated that pEXO play a key role in the establishment of maternal immune tolerance, which is critical for a successful pregnancy. To gain a better understanding of the underlying mechanism, we highlighted the advanced studies of pEXO on immune cells in pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/304797
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 1.868
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBAI, K-
dc.contributor.authorLI, X-
dc.contributor.authorZHONG, J-
dc.contributor.authorNg, EHY-
dc.contributor.authorYeung, WSB-
dc.contributor.authorLee, CL-
dc.contributor.authorChiu, PCN-
dc.date.accessioned2021-10-05T02:35:20Z-
dc.date.available2021-10-05T02:35:20Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Immunology, 2021, v. 12, p. article no. 671093-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/304797-
dc.description.abstractExosomes are a subset of extracellular vesicles with an average diameter of ~100nm. Exosomes are released by all cells through an endosome-dependent pathway and carry nucleic acids, proteins, lipids, cytokines and metabolites, mirroring the state of the originating cells. The function of exosomes has been implicated in various reproduction processes, such as embryo development, implantation, decidualization and placentation. Placenta-derived exosomes (pEXO) can be detected in the maternal blood as early as 6 weeks after conception and their levels increase with gestational age. Importantly, alternations in the molecular signatures of pEXO are observed in pregnancy-related complications. Thus, these differentially expressed molecules could be the potential biomarkers for diagnosis of the pregnancy-associated diseases. Recent studies have demonstrated that pEXO play a key role in the establishment of maternal immune tolerance, which is critical for a successful pregnancy. To gain a better understanding of the underlying mechanism, we highlighted the advanced studies of pEXO on immune cells in pregnancy.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectplacenta-
dc.subjectexosomes-
dc.subjectmaternal immune tolerance-
dc.subjectpreeclampsia-
dc.subjectgestational diabetes mellitus-
dc.titlePlacenta-Derived Exosomes as a Modulator in Maternal Immune Tolerance During Pregnancy-
dc.typeArticle-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailLee, CL: kcllee@hku.hk-
dc.identifier.emailChiu, PCN: pchiucn@hku.hk-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityLee, CL=rp02515-
dc.identifier.authorityChiu, PCN=rp00424-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2021.671093-
dc.identifier.pmid34046039-
dc.identifier.pmcidPMC8144714-
dc.identifier.scopuseid_2-s2.0-85107025092-
dc.identifier.hkuros326503-
dc.identifier.volume12-
dc.identifier.spagearticle no. 671093-
dc.identifier.epagearticle no. 671093-
dc.identifier.isiWOS:000653640000001-
dc.publisher.placeSwitzerland-

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