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Article: Characterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells

TitleCharacterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells
Authors
KeywordsAir pollution
Polycyclic aromatic hydrocarbon (PAH)
Particulate matter (PM)
Heavy metals
Primary porcine airway epithelial cells
Issue Date2022
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere
Citation
Chemosphere, 2022, v. 286 n. pt. 2, p. article no. 131741 How to Cite?
AbstractAirborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) are significant contributors leading to many human health issues. Thus, this study was designed to perform chemical analysis and biological impact of airborne particulate matter 10 (PM10) in the World heritage City of Kandy City in Sri Lanka. 12 priority PAHs and 34 metals, including 10 highly toxic HMs were quantified. The biological effects of organic extracts were assayed using an in vitro primary porcine airway epithelial cell culture model. Cytotoxicity, DNA damage, and gene expressions of selected inflammatory and cancer-related genes were also assessed. Results showed that the total PAHs ranged from 3.062 to 36.887 ng/m3. The metals were dominated by Na > Ca > Mg > Al > K > Fe > Ti, while a few toxic HMs were much higher in the air than the existing ambient air quality standards. In the bioassays, a significant cytotoxicity (p < 0.05) was observed at 300 μg/mL treatment, and significant (p < 0.05) DNA damages were noted in all treatment groups. All genes assessed were found to be significantly up-regulated (p < 0.05) after 24 h of exposure and after 48 h, only TGF-β1 and p53 did not significantly up-regulate (p < 0.05). These findings confirm that the Kandy city air contains potential carcinogenic and mutagenic compounds and thus, exposure to Kandy air may increase the health risks and respiratory tract-related anomalies.
Persistent Identifierhttp://hdl.handle.net/10722/304796
ISSN
2023 Impact Factor: 8.1
2023 SCImago Journal Rankings: 1.806
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAbayalath, N-
dc.contributor.authorMalshani, I-
dc.contributor.authorAriyaratne, R-
dc.contributor.authorZhao, S-
dc.contributor.authorZhong, G-
dc.contributor.authorGan, Z-
dc.contributor.authorManipura, A-
dc.contributor.authorSiribaddana, A-
dc.contributor.authorKarunaratne, P-
dc.contributor.authorKodithuwakku Kankanamge, SP-
dc.date.accessioned2021-10-05T02:35:19Z-
dc.date.available2021-10-05T02:35:19Z-
dc.date.issued2022-
dc.identifier.citationChemosphere, 2022, v. 286 n. pt. 2, p. article no. 131741-
dc.identifier.issn0045-6535-
dc.identifier.urihttp://hdl.handle.net/10722/304796-
dc.description.abstractAirborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) are significant contributors leading to many human health issues. Thus, this study was designed to perform chemical analysis and biological impact of airborne particulate matter 10 (PM10) in the World heritage City of Kandy City in Sri Lanka. 12 priority PAHs and 34 metals, including 10 highly toxic HMs were quantified. The biological effects of organic extracts were assayed using an in vitro primary porcine airway epithelial cell culture model. Cytotoxicity, DNA damage, and gene expressions of selected inflammatory and cancer-related genes were also assessed. Results showed that the total PAHs ranged from 3.062 to 36.887 ng/m3. The metals were dominated by Na > Ca > Mg > Al > K > Fe > Ti, while a few toxic HMs were much higher in the air than the existing ambient air quality standards. In the bioassays, a significant cytotoxicity (p < 0.05) was observed at 300 μg/mL treatment, and significant (p < 0.05) DNA damages were noted in all treatment groups. All genes assessed were found to be significantly up-regulated (p < 0.05) after 24 h of exposure and after 48 h, only TGF-β1 and p53 did not significantly up-regulate (p < 0.05). These findings confirm that the Kandy city air contains potential carcinogenic and mutagenic compounds and thus, exposure to Kandy air may increase the health risks and respiratory tract-related anomalies.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere-
dc.relation.ispartofChemosphere-
dc.subjectAir pollution-
dc.subjectPolycyclic aromatic hydrocarbon (PAH)-
dc.subjectParticulate matter (PM)-
dc.subjectHeavy metals-
dc.subjectPrimary porcine airway epithelial cells-
dc.titleCharacterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells-
dc.typeArticle-
dc.identifier.emailKodithuwakku Kankanamge, SP: suranga@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chemosphere.2021.131741-
dc.identifier.pmid34358888-
dc.identifier.scopuseid_2-s2.0-85121958328-
dc.identifier.hkuros326296-
dc.identifier.volume286-
dc.identifier.issuept. 2-
dc.identifier.spagearticle no. 131741-
dc.identifier.epagearticle no. 131741-
dc.identifier.isiWOS:000704630900008-
dc.publisher.placeUnited Kingdom-

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