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Article: Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China

TitleTerritorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China
Authors
KeywordsCOVID-19
China
Hong Kong
SARS-CoV-2
clinical demographic
Issue Date2021
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2021, v. 27 n. 1, p. 196-204 How to Cite?
AbstractInitial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
Persistent Identifierhttp://hdl.handle.net/10722/304715
ISSN
2020 Impact Factor: 6.883
2020 SCImago Journal Rankings: 2.540
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, KSS-
dc.contributor.authorNg, TTL-
dc.contributor.authorWu, AKL-
dc.contributor.authorYau, MCY-
dc.contributor.authorLao, HY-
dc.contributor.authorChoi, MP-
dc.contributor.authorTam, KKG-
dc.contributor.authorLee, LK-
dc.contributor.authorWong, BKC-
dc.contributor.authorHo, AYM-
dc.contributor.authorYip, KT-
dc.contributor.authorLung, KC-
dc.contributor.authorLiu, RWT-
dc.contributor.authorTso, EYK-
dc.contributor.authorLeung, WS-
dc.contributor.authorChan, MC-
dc.contributor.authorNg, YY-
dc.contributor.authorSin, KM-
dc.contributor.authorFung, KSC-
dc.contributor.authorChau, SKY-
dc.contributor.authorTo, WK-
dc.contributor.authorQue, TL-
dc.contributor.authorShum, DHK-
dc.contributor.authorYip, SP-
dc.contributor.authorYam, WC-
dc.contributor.authorSiu, GKH-
dc.date.accessioned2021-10-05T02:34:07Z-
dc.date.available2021-10-05T02:34:07Z-
dc.date.issued2021-
dc.identifier.citationEmerging Infectious Diseases, 2021, v. 27 n. 1, p. 196-204-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/304715-
dc.description.abstractInitial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectChina-
dc.subjectHong Kong-
dc.subjectSARS-CoV-2-
dc.subjectclinical demographic-
dc.titleTerritorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China-
dc.typeArticle-
dc.identifier.emailLeung, KSS: kssleung@hku.hk-
dc.identifier.emailWu, AKL: alanklwu@hkucc.hku.hk-
dc.identifier.emailTam, KKG: kingstkg@hku.hk-
dc.identifier.emailYam, WC: wcyam@hku.hk-
dc.identifier.authorityYam, WC=rp00313-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2701.201543-
dc.identifier.pmid33350913-
dc.identifier.pmcidPMC7774584-
dc.identifier.scopuseid_2-s2.0-85098534925-
dc.identifier.hkuros325991-
dc.identifier.volume27-
dc.identifier.issue1-
dc.identifier.spage196-
dc.identifier.epage204-
dc.publisher.placeUnited States-

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