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- Publisher Website: 10.1080/14767058.2019.1582630
- Scopus: eid_2-s2.0-85062360824
- PMID: 30760069
- WOS: WOS:000567590100014
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Article: Hepatitis E virus infection and its associated adverse feto-maternal outcomes among pregnant women in Qinhuangdao, China
Title | Hepatitis E virus infection and its associated adverse feto-maternal outcomes among pregnant women in Qinhuangdao, China |
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Authors | |
Keywords | Hepatitis Epregnancy pregnancy outcome prevalence |
Issue Date | 2020 |
Publisher | Taylor & Francis: STM, Behavioural Science and Public Health Titles. The Journal's web site is located at http://www.tandfonline.com/ijmf |
Citation | The Journal of Maternal-Fetal & Neonatal Medicine, 2020, v. 33 n. 21, p. 3647-3651 How to Cite? |
Abstract | Background and aims: The aim of this study was to investigate the positive rate of hepatitis E virus (HEV) infection and the possible adverse outcomes in pregnant women of Qinhuangdao, China.
Methods: Serum samples of 946 pregnant women were collected from July 2017 to October 2017 in Qinhuangdao First Hospital. All samples were tested for anti-HEV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). HEV RNA was tested by reverse transcription-nested polymerase chain reaction (RT-nPCR) and the PCR products were sequenced.
Results: Of the 946 samples, the positive rate of anti-HEV IgM (15/365, 4.11%), anti-HEV IgG (74/365, 20.27%) and both anti-HEV IgM and IgG (12/365, 3.29%) were significantly higher (p < .05) in third trimester pregnant women than in the first (3/288, 1.04%; 36/288, 12.5%; 4/288, 1.39%), and second trimesters (6/293, 2.05%; 29/293, 9.90%; 2/293, 0.68%). The average alanine transaminase (ALT) level (34.49 ± 10.15) and the incidence of adverse pregnancy outcomes (13/18, 72.22%) in the both anti-HEV IgM and IgG positive group were significantly higher than other groups (p < .05). HEV RNA was detected in 1/181 (0.55%) of pregnant women with a history of HEV infection and the detected HEV strain belonged to subgenotype 4a.
Conclusions: This study showed that pregnant women who have HEV infection can possibly lead to adverse pregnancy outcomes. |
Persistent Identifier | http://hdl.handle.net/10722/304713 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.649 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, M | - |
dc.contributor.author | Bu, Q | - |
dc.contributor.author | Gong, W | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Wang, L | - |
dc.contributor.author | Li, S | - |
dc.contributor.author | Sridhar, S | - |
dc.contributor.author | Woo, PCY | - |
dc.contributor.author | Wang, L | - |
dc.date.accessioned | 2021-10-05T02:34:05Z | - |
dc.date.available | 2021-10-05T02:34:05Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | The Journal of Maternal-Fetal & Neonatal Medicine, 2020, v. 33 n. 21, p. 3647-3651 | - |
dc.identifier.issn | 1476-7058 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304713 | - |
dc.description.abstract | Background and aims: The aim of this study was to investigate the positive rate of hepatitis E virus (HEV) infection and the possible adverse outcomes in pregnant women of Qinhuangdao, China. Methods: Serum samples of 946 pregnant women were collected from July 2017 to October 2017 in Qinhuangdao First Hospital. All samples were tested for anti-HEV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). HEV RNA was tested by reverse transcription-nested polymerase chain reaction (RT-nPCR) and the PCR products were sequenced. Results: Of the 946 samples, the positive rate of anti-HEV IgM (15/365, 4.11%), anti-HEV IgG (74/365, 20.27%) and both anti-HEV IgM and IgG (12/365, 3.29%) were significantly higher (p < .05) in third trimester pregnant women than in the first (3/288, 1.04%; 36/288, 12.5%; 4/288, 1.39%), and second trimesters (6/293, 2.05%; 29/293, 9.90%; 2/293, 0.68%). The average alanine transaminase (ALT) level (34.49 ± 10.15) and the incidence of adverse pregnancy outcomes (13/18, 72.22%) in the both anti-HEV IgM and IgG positive group were significantly higher than other groups (p < .05). HEV RNA was detected in 1/181 (0.55%) of pregnant women with a history of HEV infection and the detected HEV strain belonged to subgenotype 4a. Conclusions: This study showed that pregnant women who have HEV infection can possibly lead to adverse pregnancy outcomes. | - |
dc.language | eng | - |
dc.publisher | Taylor & Francis: STM, Behavioural Science and Public Health Titles. The Journal's web site is located at http://www.tandfonline.com/ijmf | - |
dc.relation.ispartof | The Journal of Maternal-Fetal & Neonatal Medicine | - |
dc.rights | Accepted Manuscript (AM) i.e. Postprint This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI]. | - |
dc.subject | Hepatitis Epregnancy | - |
dc.subject | pregnancy outcome | - |
dc.subject | prevalence | - |
dc.title | Hepatitis E virus infection and its associated adverse feto-maternal outcomes among pregnant women in Qinhuangdao, China | - |
dc.type | Article | - |
dc.identifier.email | Sridhar, S: sid8998@hku.hk | - |
dc.identifier.authority | Sridhar, S=rp02249 | - |
dc.identifier.authority | Woo, PCY=rp00430 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1080/14767058.2019.1582630 | - |
dc.identifier.pmid | 30760069 | - |
dc.identifier.scopus | eid_2-s2.0-85062360824 | - |
dc.identifier.hkuros | 325986 | - |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 21 | - |
dc.identifier.spage | 3647 | - |
dc.identifier.epage | 3651 | - |
dc.identifier.isi | WOS:000567590100014 | - |
dc.publisher.place | United Kingdom | - |